吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
蜜桃成熟1997,特黄AAAAAAA片免费视频,国产一区二区精品久久岳
Rabbit Anti-CBL2/Cy5 Conjugated antibody (bs-2757R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2757R-Cy5
英文名稱1 Rabbit Anti-CBL2/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的原癌蛋白CBL2抗體
別    名 C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; CBL 2;E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; RGD1561386; RING finger protein 55; RNF55v Signal transduction protein CBL; 4732447J05Rik; CBL_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CBL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Function:
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Subunit:
Interacts (phosphorylated at Tyr-731) with PIK3R1. Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB (By similarity). Interacts with ALK, AXL, BLK, FGR and FGFR2. Interacts with CSF1R, EPHB1, FLT1, KDR, PDGFRA and PDGFRB; regulates receptor degradation through ubiquitination. Interacts with HCK and LYN. Interacts with TEK/TIE2 (tyrosine phosphorylated).

Subcellular Location:
Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Post-translational modifications:
Phosphorylated on tyrosine residues by ALK, EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues in response to FLT1 and KIT signaling. Phosphorylated on tyrosine residues by INSR and FGR. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Not phosphorylated at Tyr-731 by FGFR3. Phosphorylated on tyrosine residues by activated CSF1R, PDGFRA and PDGFRB. Phosphorylated on tyrosine residues by HCK.
Ubiquitinated, leading to its degradation via the proteasome.

DISEASE:
Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) [MIM:613563]: A syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects. Some have an increased risk for certain malignancies, particularly juvenile myelomonocytic leukemia. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
Contains 1 RING-type zinc finger.
Contains 1 UBA domain.

Database links:

Entrez Gene: 867 Human

Entrez Gene: 12402 Mouse

Entrez Gene: 500985 Rat

Omim: 165360 Human

SwissProt: P22681 Human

SwissProt: P22682 Mouse

Unigene: 504096 Human

Unigene: 266871 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

????CBL2(Casitas B-lineage lymphoma)是一類廣泛分布的細(xì)胞內(nèi)蛋白,屬于泛素連接酶E3, Cbl參與細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)的負(fù)向調(diào)控,這對(duì)于維持細(xì)胞的內(nèi)穩(wěn)態(tài)具有重要作用。Cbl突變后可成為癌蛋白;許多腫瘤細(xì)胞則表現(xiàn)為與增殖有關(guān)的分子(如受體型蛋白酪氨酸激酶,RTK)因發(fā)生突變或其它遺傳學(xué)改變不受Cbl負(fù)調(diào)控。加強(qiáng)或重建Cbl的負(fù)調(diào)控作用,或許能夠從受體活化的上游信號(hào)開(kāi)始抑制腫瘤細(xì)胞增殖。為利用Cbl的泛素連接酶活性,并使其能夠特異性地降解某些信號(hào)轉(zhuǎn)導(dǎo)分子,從而對(duì)一些與腫瘤生長(zhǎng)有關(guān)的細(xì)胞增殖進(jìn)行負(fù)向調(diào)節(jié).
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲女人被黑人巨大进入| 黄色电影免费看| 人妻丰满熟妇无码区免费| 大又大又粗又硬又爽少妇毛片| 少妇高潮一区二区三区99| 国产18禁黄网站免费观看| 极品少妇xxxx精品少妇偷拍| 鲁一鲁一鲁一鲁一澡| 高H猛烈失禁潮喷A片在线观看| 久久成人无码国产免费播放| 无码高潮少妇毛多水多水免费 | 精品香蕉一区二区三区| 99久久国产宗和精品1上映| 人妻无码久久一区二区三区免费| 精品人妻无码一区二区三区绿| 国产肉体XXXX裸体784大胆| 女教师の爆乳BD在线观看| 亚洲精品无码MV在线观看| 手机电影网站| 亚洲AV无码久久寂寞少妇| 国产成人A亚洲精V品无码| 免费60分钟床| 亚洲AV无码国产综合专区| 免费无码毛片一区二区APP| 老司机午夜福利视频| 国产人妻精品一区二区三区不卡| 白嫩少妇BBW撒尿视频| 少妇AAA级久久久无码精品片| 日韩毛片无码永久免费看| 少妇被粗大的猛烈进出A片久久久 极品少妇被猛得白浆直流草莓视频 | 无码毛片AAA在线| 精品久久久久久无码人妻中文| 全黄裸片一29分钟免费真人版| 无码人妻久久一区二区三区APP| 精品黑人一区二区三区久久| 日韩毛片无码永久免费看| 少妇无码吹潮久久精品AV | 性色AV蜜臀AV色欲AV| 一本色道无码道DVD在线观看| 国产免费AV片无码永久免费| 欧美精品久久96人妻无码|