吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
啊灬啊灬啊灬快灬深用力,国产美女视频黄A片免费观看软件,日本动漫瀑乳H动漫啪啪免费
Rabbit Anti-phospho-BAD (Ser75)/RBITC Conjugated antibody (bs-3009R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3009R-RBITC
英文名稱1 Rabbit Anti-phospho-BAD (Ser75)/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的磷酸化相關(guān)死亡促進(jìn)因子抗體
別    名 Bad (phospho S75); Bad (phospho Ser75); p-Bad (S75);p- Bad (Ser75); p-Bad (phospho Ser75); BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Pig, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human BAD around the phosphorylation site of Ser75
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Function:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subunit:
Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins. Interacts with AKT1 and PIM3.

Subcellular Location:
Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.

Tissue Specificity:
Expressed in a wide variety of tissues.

Post-translational modifications:
Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 andSer-134 in response to survival stimuli, which blocks itspro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75promotes heterodimerization with 14-3-3 proteins. This interactionthen facilitates the phosphorylation at Ser-118, a site within theBH3 motif, leading to the release of Bcl-X(L) and the promotion ofcell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blockedby the apoptotic C-terminus cleavage product of PKN2 generated bycaspases-3 activity during apoptosis.
Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 572 Human

Entrez Gene: 12015 Mouse

Entrez Gene: 64639 Rat

Omim: 603167 Human

SwissProt: Q92934 Human

SwissProt: Q61337 Mouse

SwissProt: O35147 Rat

Unigene: 370254 Human

Unigene: 4387 Mouse

Unigene: 36696 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
又白又嫩毛又多15P| 翁与小莹浴室欢爱52章| 久久亚洲精品中文字幕| 香蕉人妻AV久久久久天天| 欧美一性一乱一交一视频| 人妻体内射精一区二区三区| 久久久国产一区二区三区| 亚洲18色成人网站WWW| av片在线观看免费| 丰满少妇作爱视频免费观看| 人妻换人妻A片爽麻豆| 隔着内裤揉搓她的花蒂H漫画| 成人H视频在线观看| 亚洲 欧美 叧类人妖| 久久夜色精品国产| 国产欧美日韩A片免费软件| 亚洲精品无码久久久久| 大胸美女视频| 免费a级黄毛片| 国产午夜三级一区二区三 | 国产AV无码专区亚洲A∨毛片| 亚洲成熟丰满熟妇高潮xxxxx| 我被脱个精光绑起来憋尿的作文| 毛片免费看| 久久精品夜色国产亚洲AV| 国产午夜精品一区二区三区| 亚洲精品97久久中文字幕无码| 人妻少妇久久久久久97人妻| 欧美激情在线播放| 扒开腿狂躁女人爽出白浆| 十九岁日本电影免费完整版观看 | 无码精品人妻一区二区三区AV| 亚洲日韩国产精品乱-久| 女人脱精光让人桶爽了| 伊人WWW22综合色| 一本大道熟女人妻中文字幕在线| 久久国产精品无码网站| 18禁网站| 亚洲熟妇无码另类久久久| 欧美老熟妇又粗又大| 中文字幕AV一区|