吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
色欲AV伊人久久大香线蕉影院,机长脔到她哭H粗话H动漫,亚洲人成无码WWW久久久
Rabbit Anti-Phospho-HDAC4 (Ser246) + HDAC5 (Ser259) + HDAC7 (Ser155)/BF555 Conjugated antibody (bs-3073R-BF555)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3073R-BF555
英文名稱1 Rabbit Anti-Phospho-HDAC4 (Ser246) + HDAC5 (Ser259) + HDAC7 (Ser155)/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的磷酸化組蛋白去乙?;?/5/7抗體
別    名 HDAC4(Phospho-Ser246); HDAC5(Phospho-Ser259); HDAC7(Phospho-Ser155); HD 4; HD4; HDAC 4; HDAC A; HDACA; Histone Deacetylase 4; Histone Deacetylase A; KIAA0288; EC 3.5.1.98; HA6116; p-HDAC4(Ser246); p-HDAC5(Ser259); p-HDAC7(Ser155).  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser246
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Subunit:
Interacts with HDAC7. Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B. Interacts with KDM5B. Interacts with MYOCD. Interacts with MORC2. Interacts with ANKRA2.

Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3. Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.

DISEASE:
Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.

Database links:

Entrez Gene: 9759 Human

Entrez Gene: 374207 Chicken

Entrez Gene: 208727 Mouse

Entrez Gene: 363287 Rat

Omim: 605314 Human

SwissProt: P83038 Chicken

SwissProt: P56524 Human

SwissProt: Q6NZM9 Mouse

SwissProt: Q99P99 Rat

Unigene: 20516 Human

Unigene: 318567 Mouse

Unigene: 23483 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲AV午夜精品一区二区三区| 精品久久久久久无码国产| 国产精品毛片久久久久久久| 国产乡下妇女做爰| 上司人妻互换中文字幕| 18禁男女爽爽爽午夜网站免费 | 我的变态室友(H)三攻一受| 欧美69久成人做爰视频| 疯狂的交换小雅小姿1~6| 精品动漫国产亚洲AV在线观看| 国产精品久久久久久无码不卡| 西西里的美丽传说在线观看| 中文字幕无码精品亚洲资源网久久| 亚洲国产成人精品无码区在线观看| 久久精品亚洲一区二区三区浴池| 国产乱子伦农村叉叉叉| 精产国品一二三产区区别| 欧美性狂猛XXXXXBBBBB| 亚洲精品婷婷无码成人A片在线| 短裙公车被强好爽H吃奶视频| 久久99热狠狠色AV蜜臀| A片粗大的内捧猛烈进出男男小说| 天堂А√在线中文在线新版| 国产人妻精品一区二区三区不卡| 成人性爱视频在线观看| 亚洲AV无码乱码在线观看,不卡| 精品无码人妻一区二区免费蜜桃| 丰满少妇作爱视频免费观看| 老熟女高潮喷了一地| 欧美成人电影| 粗了大了 整进去好爽视频| 久久夜色精品国产欧美乱| 亚洲欧美国产精品专区久久 | 精品无码黑人又粗又大又长| 国产偷窥熟女精品视频大全| 亚洲国产精品久久久久爰色欲| 少妇人妻偷人精品一区二区| 婷婷人人爽人人爽人人片| 一边摸一边抽搐一进一出| 国产午夜精品一区二区三区 | 亚洲一区二区三区无码久久|