吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
97人人模人人爽人人少妇,人妻无码αv中文字幕久久琪琪布,人妻夜夜爽天天爽三区丁香花
Rabbit Anti-Cdc25A/PE-Cy3 Conjugated antibody (bs-2758R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2758R-PE-Cy3
英文名稱1 Rabbit Anti-Cdc25A/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的細(xì)胞分裂周期蛋白25抗體
別    名 Cdc 25a; CDC25A2; Cell division cycle 25 homolog A (S. pombe); Cell division cycle 25A; Cell division cycle 25A isoform a; Cell division cycle 25A isoform b; D9Ertd393e; Dual specificity phosphatase CDC25A; EC 3.1.3.48; M phase inducer phosphatase 1; MGC115549; CDC25A; CDC25A2 CAG isoform; M-phase inducer phosphatase 1; MPIP1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  細(xì)胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human cdc25A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Subunit:
Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages.

Post-translational modifications:
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.

Similarity:
Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Database links:

Entrez Gene: 993 Human

Entrez Gene: 12530 Mouse

Entrez Gene: 171102 Rat

Omim: 116947 Human

SwissProt: P30304 Human

SwissProt: P48964 Mouse

SwissProt: P48965 Rat

Unigene: 437705 Human

Unigene: 307103 Mouse

Unigene: 11390 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CDC25家族的組成哺乳動物中CDC25家族一共包括3種同源異構(gòu)體(CDC25A、CDC25B、CDC25C),約有50%的序列同源,是一組在細(xì)胞周期調(diào)控中發(fā)揮巨大作用的蘇/酪氨酸雙功能酶 。不同的CDC25家族蛋白在細(xì)胞周期中的作用時相亦有差異,CDC25A和CDC25C分別在S期和M期發(fā)揮主要作用。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲AV乱码一区二区三区林ゆな | T66Y最新地址一地址二地址三| 亚洲AV区无码字幕中文色| 又硬又粗又大一区二区三区视频 | 国产精品美女久久久久| 日韩人妻无码精品无码中文字幕| 国产成A人亚洲精V品无码| 亚洲AV中文无码乱人伦在线观看| 国产午夜福利视频在线观看| 日欧一片内射VA在线影院| 被多个男人调教奶头玩奶头| 国产女人18毛片水真多1| 国产精品人妻无码久久久 | 日木AV无码专区亚洲AV毛片| 亚洲AV无码码潮喷在线观看| 亚洲欧美一区二区三区在线| 亚洲AV成人无码久久精品| 色偷偷噜噜噜亚洲男人| 亚洲AV在线观看| 人妻少妇无码精品视频区| 亚洲欧美日韩久久精品第一区 | 精品无码久久久久久国产| 免费看片A级毛片免费看| 性色AV浪潮AV色欲AV一区| 中文字幕日本人妻久久久免费| 欲妇荡岳丰满少妇A片24小时| JIZZJIZZ少妇亚洲水多| 波多野结衣AV无码| 丁香花在线观看免费观看图片| 久久久久久人妻一区二区三区| 熟女肥臀白浆大屁股一区二区| 欧美人与物VIDEOS另类| 曰本无码人妻丰满熟妇啪啪| 日韩内射美女人妻一区二区三区 | 又硬又粗进去爽A片免费| 亚洲AV无码专区国产乱码不卡 | 国产人A片777777久久| AV下页| 国产一区二区三区不卡AV| 成av人片一区二区三区久久| AV动漫|