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Rabbit Anti-DARPP32/BF488 Conjugated antibody (bs-2762R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2762R-BF488
英文名稱1 Rabbit Anti-DARPP32/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的多巴胺、cAMP調(diào)節(jié)磷蛋白抗體
別    名 DARPP 32; DARPP-32; Dopamine and cAMP regulated neuronal phosphoprotein; Dopamine and cAMP regulated phosphoprotein DARPP 32; Dopamine and cAMP regulated phosphoprotein DARPP32; FLJ20940; IPPD; Neuronal phosphoprotein DARPP 32; PPP1R1B; Protein phosphatase 1 regulatory (inhibitor) subunit 1B; Protein phosphatase 1 regulatory subunit 1B.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ,G)
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DARPP32
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Function:
Inhibitor of protein-phosphatase 1.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylation of Thr-34 is required for activity.

Similarity:
Belongs to the protein phosphatase inhibitor 1 family.

Database links:

Entrez Gene: 84152 Human

Entrez Gene: 19049 Mouse

Entrez Gene: 360616 Rat

Omim: 604399 Human

SwissProt: Q9UD71 Human

SwissProt: Q60829 Mouse

SwissProt: Q6J4I0 Rat

Unigene: 286192 Human

Unigene: 45372 Mouse

Unigene: 70366 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    DARPP-32通過自身不同位點(diǎn)的磷酸化對(duì)蛋白質(zhì)磷酸化和去磷酸化過程發(fā)揮著雙向調(diào)控的作用.DARRP-32在腦內(nèi)存在于接受多巴胺能投射的神經(jīng)元中,其磷酸化過程受多種神經(jīng)遞質(zhì)的調(diào)控,在信號(hào)轉(zhuǎn)導(dǎo)途徑中處于中心位置,整合多種胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo),調(diào)節(jié)神經(jīng)元的電學(xué)和化學(xué)性質(zhì)以及動(dòng)物的生理行為反應(yīng),參與多種生理功能和病理過程,包括藥物成癮、抑郁癥、精神分裂癥等.此外,DARPP-32在非神經(jīng)系統(tǒng)的功能也逐漸被人們所認(rèn)識(shí).
    多巴胺和cAMP調(diào)節(jié)的磷蛋白(dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32)是一個(gè)具有雙重功能的獨(dú)特蛋白,它既是磷酸酶(如PP-1)的抑制劑,也是蛋白激酶(如PKA)的抑制劑。
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