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Rabbit Anti-CRP/PE-Cy3 Conjugated antibody (bs-0155R-PE-Cy3)
訂購(gòu)熱線(xiàn):400-901-9800
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訂購(gòu)QQ:  400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-0155R-PE-Cy3
英文名稱(chēng)1 Rabbit Anti-CRP/PE-Cy3 Conjugated antibody
中文名稱(chēng) PE-Cy3標(biāo)記的C-反應(yīng)蛋白抗體
別    名 C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRP (151-200aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma.

Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Database links:

Entrez Gene: 1401 Human

Omim: 123260 Human

SwissProt: P02741 Human

Unigene: 76452 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

C反應(yīng)蛋白 CRP(C-reactive protin)是與C性肺炎球菌的多糖起反應(yīng)的一種蛋白,在某些細(xì)菌的感染過(guò)程中出現(xiàn)在血漿中。
CRP是在一些病理性情況下出現(xiàn)于病人血清中的一種糖蛋白,特別是在伴有肯炎癥和組織壞死疾病的急性期。血清中出現(xiàn)的這種異常蛋白能和肺炎C-多糖體發(fā)生沉淀反應(yīng),當(dāng)疾病好轉(zhuǎn)或緩解時(shí),CRP減低或消失。
臨床意義:
(1)各種急性化膿性炎癥、菌血癥、組織壞死(心肌梗塞、手術(shù)、嚴(yán)重創(chuàng)傷、燒傷等)、惡性腫瘤、結(jié)締組織病、腎移殖后急性排異反應(yīng)、急性風(fēng)濕熱、風(fēng)濕性關(guān)節(jié)炎、類(lèi)風(fēng)濕性關(guān)節(jié)炎、心肌炎急性期、肺炎、肺結(jié)核、系統(tǒng)性紅斑狼瘡、急性肝炎和闌尾炎等,血清中CRP含量可增高,它的出現(xiàn)比其它急性期的反應(yīng)物質(zhì)早,所以對(duì)疾病的早期診斷很有幫助。
CRP可以鑒別細(xì)菌炎癥或者是病毒性炎癥。細(xì)菌性炎癥CRP可以明顯增高,而病毒性炎癥CRP的血清含量一般都在正常范圍。
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