吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
娇小videodes极品,国产成人精品三级麻豆,鸡西市天气预报
Rabbit Anti-Phospho-FoxO3a (Ser318 + Ser321)/PE-Cy3 Conjugated antibody (bs-3138R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3138R-PE-Cy3
英文名稱1 Rabbit Anti-Phospho-FoxO3a (Ser318 + Ser321)/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的磷酸化叉頭蛋白3A抗體
別    名 AF6q21; AF6q21 protein; DKFZp781A0677; FKHR2; FKHRL 1; FKHRL1; FKHRL1P2; Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; Forkhead box O3; Forkhead box O3A; Forkhead box protein O3; Forkhead box protein O3A; Forkhead Drosophila homolog of in rhabdomyosarcoma like 1; Forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma like 1; Forkhead in rhabdomyosarcoma-like 1; FOX O3A; FOXO2; foxo3; FOXO3_HUMAN; FOXO3A; MGC12739; MGC31925.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human FoxO3a around the phosphorylation site of Ser318/321
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Function:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Subunit:
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1.

Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation. Phosphorylated by PIM1. Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization. Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

DISEASE:
Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 2309 Human

Entrez Gene: 56484 Mouse

Entrez Gene: 294515 Rat

Omim: 602681 Human

SwissProt: O43524 Human

SwissProt: Q9WVH4 Mouse

Unigene: 220950 Human

Unigene: 338613 Mouse

Unigene: 24593 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FOXO3a是FOX(forkhead box)蛋白家族的一個重要成員,與細(xì)胞轉(zhuǎn)化、腫瘤的發(fā)生發(fā)展及其血管生成有關(guān),是一種已知的控制細(xì)胞循環(huán)和細(xì)胞死亡的蛋白質(zhì)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
拍摄av现场失控高潮数次| 国产又粗又猛又爽又黄| 国产一区二区三精品久久久无广告| 色橹橹欧美在线观看视频高清 | 精品国产成人亚洲午夜福利| 亚洲熟妇无码另类久久久| 美女露出奶头扒开尿口| 久久精品AⅤ无码中文字字| 少妇人妻丰满做爰XXX| 久久精品国产亚洲AV大全| 国产亚洲成AV人片在线观黄桃| 亚洲狠狠婷婷综合久久久久图片| 久久久久亚洲AV成人网人人网站| 精品无码国产一区二区三区AV| 久久泄欲网| 国产偷窥熟女精品视频大全| 麻豆国产精品色欲AV亚洲三区| 国产精品无码AV无码| 99精品国产在热久久婷婷| 公与淑婷厨房猛烈进出视频| 成人免费毛片AAAAAA片| 女人扒开屁股桶爽30分钟| 开心色| 国产亚洲精品一区二区在线观看| 69久久国产露脸精品国产| 成人妇女免费播放久久久| 亚洲大码熟女在线观看| 国产精品久久久久AAAA| 精品国产污污免费网站AⅤ| 99精品久久毛片A片| 无码一区二区三区| 国产乡下三级全黄三级bd| 被黑人伦流澡到高潮HNP动漫| FREE性VIDEO西欧极品| 蜜臀AV在线| 天天爽夜夜爽人人爽,qc| 凹凸久久人人澡超碰凹凸| 777午夜精品久久AV蜜臀| 国产AV无码专区亚洲A∨毛片| 无码无套少妇毛多18PXXXX| 亚洲AV无码国产精品色午友在线|