吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
免费男人下部进女人下部视频,扒开腿狂躁女人爽出白浆
Rabbit Anti-Phospho-FoxO3a (Ser318 + Ser321)/PE-Cy5 Conjugated antibody (bs-3138R-PE-Cy5)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-3138R-PE-Cy5
英文名稱(chēng)1 Rabbit Anti-Phospho-FoxO3a (Ser318 + Ser321)/PE-Cy5 Conjugated antibody
中文名稱(chēng) PE-Cy5標(biāo)記的磷酸化叉頭蛋白3A抗體
別    名 AF6q21; AF6q21 protein; DKFZp781A0677; FKHR2; FKHRL 1; FKHRL1; FKHRL1P2; Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; Forkhead box O3; Forkhead box O3A; Forkhead box protein O3; Forkhead box protein O3A; Forkhead Drosophila homolog of in rhabdomyosarcoma like 1; Forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma like 1; Forkhead in rhabdomyosarcoma-like 1; FOX O3A; FOXO2; foxo3; FOXO3_HUMAN; FOXO3A; MGC12739; MGC31925.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human FoxO3a around the phosphorylation site of Ser318/321
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Function:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Subunit:
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1.

Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation. Phosphorylated by PIM1. Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization. Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

DISEASE:
Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 2309 Human

Entrez Gene: 56484 Mouse

Entrez Gene: 294515 Rat

Omim: 602681 Human

SwissProt: O43524 Human

SwissProt: Q9WVH4 Mouse

Unigene: 220950 Human

Unigene: 338613 Mouse

Unigene: 24593 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FOXO3a是FOX(forkhead box)蛋白家族的一個(gè)重要成員,與細(xì)胞轉(zhuǎn)化、腫瘤的發(fā)生發(fā)展及其血管生成有關(guān),是一種已知的控制細(xì)胞循環(huán)和細(xì)胞死亡的蛋白質(zhì)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
成人夜色视频网站在线观看| 拍摄av现场失控高潮数次| 香肠派对比赛服| 国产日产欧产美| 甜蜜惩罚我是看守专用宠物 | 无码精品AV久久久奶水| 日韩人妻无码免费视频一区二区三区| 亚洲午夜AV久久久精品影院色戒| 性国产SE╳O色欲A片欢迎观看| 国产精品久久久| 成人AAA片一区国产精品| 少妇愉情理伦片高潮日本| 天天操,天天干,天天日| 2022最新韩国理伦片在线观看| 风韵多水的老熟妇| 厨房一次又一次的索要| 99久久99久久精品国产片果冻| 6080YYY午夜理论AA片| 精品欧美А∨无码黑人| 国产人A片777777久久| 亚洲AV无码精品色午夜果冻不卡| 国产精品| 国产精品久久一区二区三区| 精品深夜AV无码一区二区| 欧美裸体XXXX极品少妇| 国产精品无码不卡一区二区三区| 偷窥学校女厕撒尿BBBBB| 国产又色又爽又刺激在线播放| 99精品国产一区二区| 久久无码专区国产精品S| 无码少妇A片一区二区三区| 亚洲AV无码乱码国产精品FC2| 看同性男AA片| 最新中文字幕AV专区| 少妇极品熟妇人妻无码| 国产精品人成视频免费播放| 久久精品无码一区二区三区免费| 精品久久久久久中文字幕人妻最新| 少妇无码一区二区三区免费| 少妇愉情理伦片高潮日本| WWW夜插内射视频网站|