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Rabbit Anti-phospho-GCN2 (Thr667)/PE-Cy5 Conjugated antibody (bs-3156R-PE-Cy5)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3156R-PE-Cy5
英文名稱1 Rabbit Anti-phospho-GCN2 (Thr667)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的磷酸化蛋白激酶GCN2蛋白抗體
別    名 GCN2 (phospho T667); p-GCN2 (phospho T667); EIF2AK4; Eukaryotic Translation Initiation Factor 2-alpha kinase 4; GCN2-like protein; KIAA1338; E2AK4_HUMAN; Eif2ak4; Eukaryotic Translation Initiation Factor 2 alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; MGCN2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 181kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human GCN2 around the phosphorylation site of Thr667
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Autophosphorylated on threonine residues.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Contains 2 protein kinase domains.
Contains 1 RWD domain.

Database links:

Entrez Gene: 440275 Human

Entrez Gene: 27103 Mouse

Entrez Gene: 114859 Rat

Omim: 609280 Human

SwissProt: Q9P2K8 Human

SwissProt: Q9QZ05 Mouse

Unigene: 656673 Human

Unigene: 217616 Mouse

Unigene: 8333 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GCN2蛋白的作用;可能是將短期記憶變成長(zhǎng)期記憶的一個(gè)主控調(diào)節(jié)因子, GCN2蛋白在長(zhǎng)期記憶形成中功能的發(fā)現(xiàn)將可能幫助研究人員開(kāi)發(fā)出提高記憶力喪失的病人提高記憶力。
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