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Rabbit Anti-TRPM2/PE-Cy5.5 Conjugated antibody (bs-2888R-PE-Cy5.5)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2888R-PE-Cy5.5
英文名稱1 Rabbit Anti-TRPM2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的瞬時(shí)受體電位離子通道蛋白/M亞家族抗體
別    名 EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 165kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death.

Subunit:
Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Contains 1 nudix hydrolase domain.

Database links:

Entrez Gene: 7226 Human

Entrez Gene: 28240 Mouse

Entrez Gene: 294329 Rat

Omim: 603749 Human

SwissProt: O94759 Human

SwissProt: Q5KTC0 Mouse

SwissProt: Q91YD4 Mouse

SwissProt: Q5G856 Rat

Unigene: 369759 Human

Unigene: 276762 Mouse

Unigene: 214495 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TRPM2 屬于瞬時(shí)受體電位離子通道蛋白家族的M亞家族,是一種非選擇性的陽(yáng)離子通道蛋白, 是離子通道蛋白參與了單核細(xì)胞的氧化應(yīng)激應(yīng)答反應(yīng),與老年性癡呆等神經(jīng)退行疾病的發(fā)生與發(fā)展有著十分密切的聯(lián)系.
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