吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
性少妇FREESEXVIDEOS高清,成人毛片100免费观看
Rabbit Anti-DHPR alpha 1/PE-Cy7 Conjugated antibody (bs-2806R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2806R-PE-Cy7
英文名稱1 Rabbit Anti-DHPR alpha 1/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的L-型電壓依賴型鈣通道α抗體
別    名 alpha-1 polypeptide; cardiac muscle; isoform 1; L type; CAC1C_HUMAN; CACH 2; DHPR alpha 1; VDCC-L alpha; CACH2; CACN 2; CACN2; CACNA1C; CACNL1A1; Calcium channel; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle; Calcium channel voltage dependent L type alpha 1C subunit; CaV1.2; CCHL1A1; DHPR alpha 1 subunit; LQT8; TS; Voltage dependent L type calcium channel alpha 1C subunit; Voltage dependent L type calcium channel subunit alpha 1C; Voltage gated calcium channel alpha subunit Cav1.2; Voltage gated calcium channel subunit alpha Cav1.2; Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 249kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DHPR alpha 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq]

Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subunit:
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4. Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane. Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Tissue Specificity:
Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

Post-translational modifications:
Phosphorylation by PKA activates the channel.

DISEASE:
Defects in CACNA1C are the cause of Timothy syndrome (TS) [MIM:601005]. TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.
Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3) [MIM:611875]. A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.

Database links:

Entrez Gene: 775 Human

Entrez Gene: 12288 Mouse

Entrez Gene: 100144322 Rabbit

Entrez Gene: 24239 Rat

Omim: 114205 Human

SwissProt: Q13936 Human

SwissProt: Q01815 Mouse

SwissProt: P15381 Rabbit

SwissProt: P22002 Rat

Unigene: 118262 Human

Unigene: 436656 Mouse

Unigene: 9827 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

L型鈣通道廣泛分布于心肌細(xì)胞膜上,尤其T管上含量最為豐富,是心肌細(xì)胞膜的主要鈣通道類型。L型鈣通道的開閉主要受膜電位變化的影響,是電壓依賴性鈣通道,激活電位-40~-30mV,失活電位-20mV。L型鈣通道開放后持續(xù)的時(shí)間長較長,激活占時(shí)20~30ms,失活更慢(100~300ms),又稱為慢鈣通道。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
狠狠色噜噜狠狠狠888米奇视频 | 国产无遮挡又黄又爽在线观看| 欧美大荫蒂毛茸茸视频| 两女女百合互慰AV赤裸无遮挡| 国精品人妻无码一区二区三区蜜柚| 精人妻无码一区二区三区| 中文字幕爆乳JULIA女教师| 久久久久亚洲精品无码蜜桃| 自拍偷在线精品自拍偷无码专区| 亚洲AV无码久久| 国语精彩对白在线视频| 人妻丰满熟妇无码区免费| 久久人人爽人人爽人人片AV高清| 少妇粉嫩小泬喷水视频WWW| 精品无码人妻一区二区免费蜜桃| 含着奶头搓揉深深挺进| 亚洲视频一区| 亚洲精品久久无码AV片俺去也| 麻花传媒MV一二三区别在哪里看| 丰满少妇张开大白腿| 一本大道AV伊人久久综合| 欧美老妇交乱视频在线观看 | 中文字幕人妻丝袜乱一区三区| 国产成人一区二区三区影 | 国产成人A亚洲精V品无码| 亚洲AV片一区二区三区| 国产成人无码A区在线观看视频| 性无码一区二区三区在线观看| 免费看美女被靠到爽的视频| 国产深夜男女无套内射| 97久久精品人人做人人爽| 美女脱了内裤张开腿让男人桶网站| 99久久人妻精品免费二区| 久久夜色精品国产| 妻子4免费完整版中文版| 亚洲精品中文字幕乱码三区| 国产精品视频在线观看| 日韩精品无码一本二本三本色| 欧美性生交XXXXX久久久| 欧美XXXX色视频在线观看| 肉乳乱无码A片观看免费|