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Rabbit Anti-CACNB2/AP Conjugated antibody (bs-2996R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2996R-AP
英文名稱1 Rabbit Anti-CACNB2/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的L-型電壓依賴型鈣通道β抗體
別    名 Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L Beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit; CACB2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CACNB2 (621-670aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 783 Human

Entrez Gene: 12296 Mouse

Entrez Gene: 116600 Rat

Omim: 600003 Human

SwissProt: Q08289 Human

SwissProt: Q8CC27 Mouse

SwissProt: Q8VGC3 Rat

Unigene: 59093 Human

Unigene: 313930 Mouse

Unigene: 10739 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

電壓依賴性鈣通道(VDCC)是生物體內(nèi)一大類鈣通道蛋白,隨著膜電位的改變而出現(xiàn)通道的開放、關(guān)閉和失活,調(diào)節(jié)細(xì)胞內(nèi)Ca2+濃度,最終產(chǎn)生生物學(xué)效應(yīng).其亞型結(jié)構(gòu)各異,VDCC β亞基具有調(diào)節(jié)其通道活性的作用,VDCC存在的普遍性決定了其作用的廣泛性.在胰腺、心、腦、腎上腺、視網(wǎng)膜及神經(jīng)等組織器官均有不同程度的分布.
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