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Rabbit Anti-Cyclin A2/AP Conjugated antibody (bs-0571R-AP)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0571R-AP
英文名稱(chēng)1 Rabbit Anti-Cyclin A2/AP Conjugated antibody
中文名稱(chēng) 堿性磷酸酶(AP)標(biāo)記的周期素A2抗體
別    名 CCN1; CCNA; CCNA2; Cyclin A2; CCNA2_HUMAN; Cyclin-A2; CCNA2; Cyclin-A.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin A
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008].

Function:
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

Subunit:
Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER.

Subcellular Location:
Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER.

Post-translational modifications:
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).

Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.

Database links:

Entrez Gene: 281667 Cow

Entrez Gene: 890 Human

Entrez Gene: 12428 Mouse

Entrez Gene: 114494 Rat

Omim: 123835 Human

SwissProt: P30274 Cow

SwissProt: P20248 Human

SwissProt: P51943 Mouse

Unigene: 58974 Human

Unigene: 4189 Mouse

Unigene: 13094 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin A 可以出現(xiàn)在所有類(lèi)型的細(xì)胞。各周期素可出現(xiàn)在不同的細(xì)胞增殖周期中。能結(jié)合和激活CDK2激酶,促進(jìn)細(xì)胞G1/S和G2/M增殖周期的轉(zhuǎn)化。
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