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Rabbit Anti-NUMB/Biotin Conjugated antibody (bs-3510R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3510R-Bio
英文名稱1 Rabbit Anti-NUMB/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的膜相關(guān)蛋白Numb抗體
別    名 c14_5527; C14orf41; FLJ31314; h Numb; h-Numb; Numb; Numb homolog (Drosophila); Numb homolog; Numb protein homolog; NUMB_HUMAN; Protein numb homolog; Protein S171; S171.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  細(xì)胞膜受體  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NUMB
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Subunit:
Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.

Subcellular Location:
Membrane; Peripheral membrane protein.

Post-translational modifications:
Phosphorylated on Ser-276 and Ser-295 by CaMK1.
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Similarity:
Contains 1 PID domain.

Database links:

Entrez Gene: 8650 Human

Entrez Gene: 18222 Mouse

Entrez Gene: 29419 Rat

Omim: 603728 Human

SwissProt: P49757 Human

SwissProt: Q9QZS3 Mouse

SwissProt: Q2LC84 Rat

Unigene: 654609 Human

Unigene: 714879 Human

Unigene: 4390 Mouse

Unigene: 102078 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

膜相關(guān)蛋白Numb是細(xì)胞命運(yùn)決定因子:在細(xì)胞有絲分裂期,Numb選擇性地分布于細(xì)胞的一側(cè),在胞質(zhì)分裂后則被分配于一個(gè)子細(xì)胞,Numb通過抑制跨膜受體Notch而發(fā)揮作用, Numb信號(hào)途徑在前體細(xì)胞的神經(jīng)元調(diào)控方面起著重要作用.
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