吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
日本人妻伦在线中文字幕,亚洲欧美精品午睡沙发,麻豆传媒视频
Rabbit Anti-Phospho-Paxillin (Tyr118)/AP Conjugated antibody (bs-3352R-AP)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3352R-AP
英文名稱1 Rabbit Anti-Phospho-Paxillin (Tyr118)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的磷酸化樁蛋白Paxillin抗體
別    名 p-paxillin; p-PXN(Y118); p-PXN(Tyr118); Paxillin (phospho Y118); Paxillin (phospho Tyr118); p-Paxillin (Tyr118); Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; PXN; PXN protein; FLJ16691; FLJ23042; FLJ16691; PAXI_HUMAN; Paxillin; PXN protein.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Paxillin around the phosphorylation site of Tyr118
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).

Function:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Subunit:
Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery.

Post-translational modifications:
Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion.

Similarity:
Belongs to the paxillin family.
Contains 4 LIM zinc-binding domains.

Database links:

Entrez Gene: 5829 Human

Entrez Gene: 19303 Mouse

Entrez Gene: 360820 Rat

Omim: 602505 Human

SwissProt: P49023 Human

SwissProt: Q8VI36 Mouse

SwissProt: Q66H76 Rat

Unigene: 446336 Human

Unigene: 18714 Mouse

Unigene: 75 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Paxillin是一種分子量為68KDa的局部粘附蛋白,參與腫瘤細(xì)胞的粘附與轉(zhuǎn)移。主要用于各種惡性腫瘤的研究。 Paxillin 蛋白是胞外基質(zhì)細(xì)胞粘附(粘著斑)位點(diǎn)上肌動(dòng)蛋白-膜附著的細(xì)胞骨架蛋白。 Paxillin 在整合蛋白的信號(hào)傳導(dǎo)中起著非常重要的作用,整合蛋白介導(dǎo)的細(xì)胞骨架的再組織需要,paxillin 酪氨酸殘基的磷酸化。 Paxillin 被粘著斑激酶 (FAK)在其118位的酪氨酸殘基處磷酸化。已經(jīng)證明,paxillin 118位和31位兩個(gè)酪氨酸的磷酸化對(duì)于MM1癌細(xì)胞的遷移是重要的。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧洲美女与动交ZOZ0Z| 国产精品久久久久久吹潮| 无码精品视频一区二区三区| 天堂资源最新在线| 人妻少妇精品无码专区二区| 精品人妻人人做人人爽夜夜爽| 国产+高潮+白浆+无码| 亚洲H在线播放在线观看H| 人人爽久久涩噜噜噜AV| 老同学3免费完整版在线观看| 精品无码一区二区三区亚洲桃色| 全国最大成人网站| 樱桃视频大全免费高清版| 三年片在线观看免费大全爱奇艺| 国模无码一区二区三区| 妺妺窝人体色WWW聚色窝仙踪| 免费视频网站| 亚洲小说区图片区另类春色| 久久精品国产精品亚洲精品| 麻豆人妻少妇精品无码专区| 厨房玩弄丝袜人妻系列国产电影 | 99久久无码一区人妻A片潘金莲| 久久久久久亚洲AV无码专区| 俄罗斯大荫蒂女人毛茸茸| 人妻少妇AV中文字幕乱码| 精品久久久久久无码人妻| 苍井そら无码av| 老熟女高潮一区二区三区| 天堂网在线观看| 色婷婷av一区二区三区| 波多野结衣456| 国产猛男猛女超爽免费视频| 国产成人AV| 欧美狂野另类XXXXOOOO| 久久亚洲AV成人无码国产| 无码免费一区二区三区| 久久泄欲网| 久久精品A亚洲国产V高清不卡| 国内老熟妇对白XXXXHD| 国产美女极度色诱视频WWW| 国产精品无码专区AV在线播放|