吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久女婷五月综合色啪小说,欧美大肥婆大肥BBBBB,孕妇滴着奶水做着爱A
Rabbit Anti-Phospho-Paxillin (Tyr118)/PE-Cy7 Conjugated antibody (bs-3352R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3352R-PE-Cy7
英文名稱1 Rabbit Anti-Phospho-Paxillin (Tyr118)/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的磷酸化樁蛋白Paxillin抗體
別    名 p-paxillin; p-PXN(Y118); p-PXN(Tyr118); Paxillin (phospho Y118); Paxillin (phospho Tyr118); p-Paxillin (Tyr118); Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; PXN; PXN protein; FLJ16691; FLJ23042; FLJ16691; PAXI_HUMAN; Paxillin; PXN protein.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Paxillin around the phosphorylation site of Tyr118
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).

Function:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Subunit:
Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery.

Post-translational modifications:
Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion.

Similarity:
Belongs to the paxillin family.
Contains 4 LIM zinc-binding domains.

Database links:

Entrez Gene: 5829 Human

Entrez Gene: 19303 Mouse

Entrez Gene: 360820 Rat

Omim: 602505 Human

SwissProt: P49023 Human

SwissProt: Q8VI36 Mouse

SwissProt: Q66H76 Rat

Unigene: 446336 Human

Unigene: 18714 Mouse

Unigene: 75 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Paxillin是一種分子量為68KDa的局部粘附蛋白,參與腫瘤細(xì)胞的粘附與轉(zhuǎn)移。主要用于各種惡性腫瘤的研究。 Paxillin 蛋白是胞外基質(zhì)細(xì)胞粘附(粘著斑)位點(diǎn)上肌動(dòng)蛋白-膜附著的細(xì)胞骨架蛋白。 Paxillin 在整合蛋白的信號(hào)傳導(dǎo)中起著非常重要的作用,整合蛋白介導(dǎo)的細(xì)胞骨架的再組織需要,paxillin 酪氨酸殘基的磷酸化。 Paxillin 被粘著斑激酶 (FAK)在其118位的酪氨酸殘基處磷酸化。已經(jīng)證明,paxillin 118位和31位兩個(gè)酪氨酸的磷酸化對(duì)于MM1癌細(xì)胞的遷移是重要的。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
精品亚洲麻豆1区2区3区| B站禁止转播404入口| 欧美午夜精品一区二区蜜桃 | 韩国伦理电影网站| 欧洲亚洲国产精华液| 国产精品久久777777| 在线亚洲人成电影网站色WWW| 丰满多毛的大隂户毛茸茸 | 被迫多次高潮抽搐| 国内精品一区二区三区| 久久女婷五月综合色啪小说 | 久久精品国产精品亚洲精品| 免费人成在线观看网站| 熟妇高潮喷沈阳45熟妇高潮喷| 日本无遮挡边做边爱边摸| 香蕉久久夜色精品升级完成| 精品久久人妻AV中文字幕| CHINESE熟女熟妇1乱| japanesexxxx极品少妇| 妓院一钑片免看黄大片| 蜜臀AV在线播放| 男女做爰吃奶猛烈叫床视频电影| 久久女婷五月综合色啪小说| 亚洲午夜无码久久久久| 亚洲精品久久激情国产片| 中文字幕精品av乱码在线| 亚洲精品WWW久久久久久| 交换俱乐部娇妻奶呻吟啊视频| 无码人妻精品一区二区三区不卡| 亚洲码欧美码一区二区三区| 久久精品熟女亚洲AV麻豆| 亚洲AV无码一区二区三区系列| 无码毛片AAA在线| WWW夜插内射视频网站| 久久久久久久做爰片无码| 大陆熟妇丰满多毛XXXX| 国产又色又爽又高潮免费| 久久久久无码国产精品一区| 在线观看国产一区二区三区| 国产一区二区精品久久岳| 性色AV无码久久一区二区三区|