吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關于我們  聯(lián)系我們
欧美大荫蒂AV高潮,成人免费看吃奶视频网站
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-E2F1/BF555 Conjugated antibody (bs-0599R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0599R-BF555
英文名稱1 Rabbit Anti-E2F1/BF555 Conjugated antibody
中文名稱 BF555標記的轉(zhuǎn)錄因子E2F-1抗體
別    名 E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human E2F1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Function:
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1. Interacts with ARID3A. Binds EAPP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein pRB. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 1869 Human

Entrez Gene: 13555 Mouse

Entrez Gene: 399489 Rat

Omim: 189971 Human

SwissProt: Q01094 Human

SwissProt: Q61501 Mouse

SwissProt: O09139 Rat

Unigene: 654393 Human

Unigene: 18036 Mouse

Unigene: 72471 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉(zhuǎn)錄調(diào)節(jié)因子(Transcriptin Regulators)
E2F1—屬于調(diào)節(jié)性轉(zhuǎn)錄因子E2F家族。有學者認為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細胞中其他生長促進或抑制性蛋白質(zhì)水平和(或)活性決定,同時與細胞所處環(huán)境及器官特異性有關。在控制細胞周期和腫瘤抑制基因蛋白的活性方面起關鍵作用。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品国色综合久久| 亚洲色偷偷综合亚洲AV78| 国产精品毛片一区二区三区| 亚洲国产精品无码专区| 苍井空亚洲精品AA片在线播放| 精品人妻系列无码人妻免费视频| 天干天干天啪啪夜爽爽99| 久久久无码精品亚洲日韩啪啪网站 | 欧美乱大交XXXXX潮喷| 精品夜夜爽欧美毛片视频| 国产深夜男女无套内射| 人妻少妇无码精品视频区| 青青草原综合久久大伊人精品| 最近中文字幕国语免费高清6| 久久综合九色综合欧美狠狠| 丁香婷婷综合激情五月色| 亚洲国产精品久久久久婷婷老年| 伴郎粗大的内捧猛烈进出第一章| 中文字幕av一区二区三区| 少妇特黄A一区二区三区| 无码一区二区三区在线| 国产特级毛片AAAAAA毛片| 隔壁人妻偷人BD中字| 亚洲精品无码久久久影院相关影片| 日本特黄特色AAA大片免费 | XXXXA特别高潮| 亚洲 欧美 激情 小说 另类| А√最新版天堂资源在线| 国产精品久久久久久无码| 一边吃奶一边添P好爽故事| 日本VA欧美VA精品发布| 在办公室伦流澡到高潮H| 99蜜桃在线观看免费视频网站| 麻豆国产尤物AV尤物在线观看| 精品人妻无码一区二区三区4| 日本夜爽爽一区二区三区| 狠狠色噜噜狠狠狠狠7777米奇 | 日韩欧美一区二区三区免费观看 | 97久久精品亚洲中文字幕无码| 上司人妻被下属侵犯HD| 欧美成人一区二区三区|