| 產(chǎn)品編號(hào) | bs-3650R-BF488 |
| 英文名稱1 | Rabbit Anti-HOXB4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的HOXB4抗體 |
| 別 名 | Homeo box 2F; Homeo box B4; Homeobox 2F; Homeobox B4; Homeobox protein Hox B4; Homeobox protein HoxB4; HOX 2; Hox 2.6; Hox 2F; HOX B4; HOX2; HOX-2 Hox2.6; Hox2F; HOXB 4; HOXB-4. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOXB4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Subcellular Location: Nucleus. Similarity: Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. OXB4通過激活不同的信號(hào)通路增強(qiáng)HSC的自我更新,同時(shí)又不影響維持正常穩(wěn)態(tài)造血的調(diào)控機(jī)制。提高HOXB4的表達(dá)水平,能夠極大地增強(qiáng)HSC的自我更新功能,但基本不影響細(xì)胞的分化、系特異性及終末細(xì)胞的形態(tài)和功能。另外，HOXB4還可增強(qiáng)胚胎干細(xì)胞(embryonic stem cell,ESC)的造血潛能,促進(jìn)ESC向造血細(xì)胞分化。 |
