吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
夜精品A片一区二区三区无码白浆 国产精品久久人妻无码网站仙踪林 ,国产a片,欧美性猛交XXXX乱大交蜜桃
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Paxillin (Tyr31)/BF350 Conjugated antibody (bs-3744R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3744R-BF350
英文名稱1 Rabbit Anti-Phospho-Paxillin (Tyr31)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化樁蛋白Paxillin抗體
別    名 Paxillin (phospho Y31); p-Paxillin (phospho Y31); PXN(phospho Y31); Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; PXN; PXN protein; FLJ16691; FLJ23042; PAXI_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Paxillin around the phosphorylation site of Tyr31
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Function:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Subunit:
Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery.

Post-translational modifications:
Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion.

Similarity:
Belongs to the paxillin family.
Contains 4 LIM zinc-binding domains.

Database links:

Entrez Gene: 5829 Human

Entrez Gene: 19303 Mouse

Entrez Gene: 360820 Rat

Omim: 602505 Human

SwissProt: P49023 Human

SwissProt: Q8VI36 Mouse

SwissProt: Q66H76 Rat

Unigene: 446336 Human

Unigene: 18714 Mouse

Unigene: 75 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Paxillin是一種分子量為68KDa的局部粘附蛋白,參與腫瘤細胞的粘附與轉移。主要用于各種惡性腫瘤的研究。 Paxillin 蛋白是胞外基質細胞粘附(粘著斑)位點上肌動蛋白-膜附著的細胞骨架蛋白。 Paxillin 在整合蛋白的信號傳導中起著非常重要的作用,整合蛋白介導的細胞骨架的再組織需要,paxillin 酪氨酸殘基的磷酸化。 Paxillin 被粘著斑激酶 (FAK)在其118位的酪氨酸殘基處磷酸化。已經(jīng)證明,paxillin 118位和31位兩個酪氨酸的磷酸化對于MM1癌細胞的遷移是重要的。
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品人妻无码AV一区二区| 亚洲国产精品无码专区| 国产99在线 | 欧美| 肥老熟妇伦子伦456视频| 亚洲日韩AV无码中文字幕美国| 少妇高潮抽搐无码AV久久| 成人无遮挡18禁免费视频| 欧美虐SM另类残忍视频| 天天夜碰日日摸日日澡性色AV| 成人做爰WWW免费看视频日本| 西西里的美丽传说在线观看| 国产999精品久久久久久| 无码国产一区二区三区四区公司| 久久久久女人精品毛片| 精品乱人伦一区二区三区| 女人张开腿让男人桶爽| 久久97精品久久久久久久不卡| 久久久久99精品成人片三人毛片 | 无码精品一区二区三区在线| 日韩亚洲av人人夜夜澡人人爽| 亚洲精品无码久久久久久久| 欧美丰满熟妇BBBBBB百度| 中国丰满人妻VIDEOSHD| 久久九九久精品国产免费直播| 亚洲精品色午夜无码专区日韩| 亚洲精品久久久久久久观小说| 欧美高清性xxxxhdvideosex| 亚洲无码在线播放| japanesexxxx极品少妇| 少妇厨房愉情理9仑片视频| 狠狠色噜噜狠狠狠狠7777米奇| 国产99久一区二区三区A片| 色噜噜狠狠色综合日日| 亚洲久热无码AV中文字幕 | 色哟哟网站入口在线观看视频| 亚洲精品一区三区三区在线观看| 无码人妻精品中文字幕| 无码人妻久久一区二区三区不卡| 丝袜美腿一区二区三区| 亚洲久热无码AV中文字幕| WWW国产精品内射老熟女|