吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国内老熟妇对白XXXXHD,亚洲毛片
Rabbit Anti-PER1 protein/PE-Cy5 Conjugated antibody (bs-2350R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2350R-PE-Cy5
英文名稱1 Rabbit Anti-PER1 protein/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的節(jié)律抑制蛋白PER1抗體
別    名 Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pacemaker protein Rigui; hPER 1; hPER; hPER1; KIAA0482; MGC88021; PER 1; PER; PER1; PER1 protein; PER1_HUMAN; Period 1; Period circadian protein homolog 1; Period drosophila homolog of; Period homolog 1; Period1; RIGUI.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  神經(jīng)生物學(xué)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PER1 protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.

Function:
Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme (By similarity).

Subunit:
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1 (By similarity). Binding to CSNK1G2 triggers proteasomal degradation.

Subcellular Location:
Nucleus (By similarity). Cytoplasm (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity).

Tissue Specificity:
Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.

Post-translational modifications:
Phosphorylated on serine residues by CSNK1E. Also can be phosphorylated by the delta isoform. Phosphorylation by CSNK1 retains PER1 in the cytoplasm and leads to its ubiquitination and subsequent degradation.
Ubiquitinated (By similarity).

Similarity:
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

Database links:

Entrez Gene: 516318 Cow

Entrez Gene: 489488 Dog

Entrez Gene: 100731177 Guinea pig

Entrez Gene: 100073046 Horse

Entrez Gene: 5187 Human

Entrez Gene: 18626 Mouse

Entrez Gene: 100151739 Pig

Entrez Gene: 287422 Rat

Omim: 602260 Human

SwissProt: O15534 Human

SwissProt: O35973 Mouse

SwissProt: Q8CHI5 Rat

Unigene: 445534 Human

Unigene: 7373 Mouse

Unigene: 34433 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Per1蛋白的作用是機(jī)體生理節(jié)奏調(diào)節(jié)的核心基因,也是影響腫瘤發(fā)生發(fā)展的重要蛋白。調(diào)節(jié)機(jī)體生理節(jié)奏、調(diào)控細(xì)胞周期和促進(jìn)DNA損傷修復(fù)等作用。Per1廣泛參與了細(xì)胞的周期調(diào)控、DNA損傷修復(fù)、細(xì)胞凋亡和腫瘤細(xì)胞增殖等過程
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产成人精品一区二区三区无码 | 亚洲精品乱码久久久久蜜桃 | 亚洲精品无码久久毛片 | 一本色道无码道DVD在线观看| 欧美高清性色生活片免费观看| 欧美日韩中文国产一区发布| 久久久久亚洲AV片无码下载蜜桃 | 人妻 日韩 欧美 综合 制服| 亚洲AV无码成H在线观看| 国产精品久久久久一区二区三区 | 蜜臀AV色欲A片无码精品一区| 97精品国产手机| 99国内精品久久久久久久| 亚洲熟妇色XXXXX欧美老妇| 国产精品99久久免费观看| 日本人妻伦在线中文字幕| 蜜桃臀无码内射一区二区三区| 大肉大捧一进一出视频| 无套中出丰满人妻无码| 丰满多毛的大隂户毛茸茸 | 精品少妇人妻AV一区二区三区| ZOZ○ZO女人和另类ZOZ0| 最近中文字幕在线看免费完整版| 人善交XUANWEN200| 亚洲综合AV一区二区三区 | 久久女婷五月综合色啪小说| 人妻夜夜爽天天爽| 欧美激情综合五月色丁香| 亚洲国产精品久久人人爱| 国产精品沙发午睡系列| 好涨嗯太深了嗯啊用力别停| 中文字幕亚洲乱码熟女一区二区 | 欧美一性一乱一交一视频| 亚洲AV无码成人精品区狼人影院| 日本丰满少妇无码AⅤ波多| 中文字幕人妻女友一区蜜芽视频| 亚洲av高清一区二区三区| GOGOGO日本免费观看电视| 成人区人妻精品一区二区不卡视频 | 少妇做爰特黄A片免费看| 亚洲精品中文字幕乱码三区|