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Rabbit Anti-ETFB/PE-Cy3 Conjugated antibody (bs-3937R-PE-Cy3)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-3937R-PE-Cy3
英文名稱(chēng)1 Rabbit Anti-ETFB/PE-Cy3 Conjugated antibody
中文名稱(chēng) PE-Cy3標(biāo)記的電子轉(zhuǎn)移黃素蛋白β肽/黃素蛋白抗體
別    名 Flavoprotein; Beta ETF; FP; Beta-ETF; Electron transfer flavoprotein beta polypeptide; Electron transfer flavoprotein beta subunit; Electron transfer flavoprotein subunit beta; Electron transferring flavoprotein beta polypeptide; etfB; ETFB_HUMAN; FP585; MADD.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  線粒體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ETFB
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase.

Function:
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

Subunit:
Heterodimer of an alpha and a beta subunit.

Subcellular Location:
Mitochondrion matrix.

Tissue Specificity:
Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.

DISEASE:
Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B) [MIM:231680]. GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

Similarity:
Belongs to the ETF beta-subunit/fixA family.

Database links:
UniProtKB/Swiss-Prot: P38117.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

黃素蛋白是由一條多肽結(jié)合1個(gè)輔基組成的酶類(lèi),不是脂溶性。結(jié)合的輔基可以是FAD或FMN,它們是維生素B2的衍生物,每個(gè)輔基能夠接受和提供兩個(gè)質(zhì)子和電子。線粒體中的黃素蛋白主要是電子傳遞鏈中NADH脫氫酶和TCA循環(huán)中的琥珀酸脫氫酶。
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