| 產(chǎn)品編號(hào) | bs-1238R-AP |
| 英文名稱(chēng)1 | Rabbit Anti-HO-2/AP Conjugated antibody |
| 中文名稱(chēng) | 堿性磷酸酶（AP）標(biāo)記的血紅素氧合酶2抗體 |
| 別 名 | Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; HMOX 2; HMOX2; HMOX2 protein; HO 2; HO2; HMOX2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 合成與降解 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HO-2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Summary: catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [SUBCELLULAR LOCATION] Microsome. Endoplasmic reticulum. [INDUCTION] Heme oxygenase 2 activity is non-inducible. [SIMILARITY] Belongs to the heme oxygenase family. Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Subcellular Location: Microsome. Endoplasmic reticulum. Similarity: Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats. Database links: Entrez Gene: 3163 Human Entrez Gene: 15369 Mouse Entrez Gene: 100009523 Rabbit Omim: 141251 Human SwissProt: P30519 Human SwissProt: O70252 Mouse SwissProt: P43242 Rabbit Unigene: 284279 Human Unigene: 272866 Mouse Unigene: 10241 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） 血紅素氧合酶是目前發(fā)現(xiàn)生物體內(nèi)最易被誘導(dǎo)產(chǎn)生的抗氧化酶類(lèi)，其抗氧化作用與它的催化分解產(chǎn)物即膽綠素、膽紅素、NO、鐵離子和鐵蛋白有關(guān)。 血紅素氧合酶-2基因缺失對(duì)血紅素誘導(dǎo)的氧化應(yīng)激性導(dǎo)致的組織損傷具有保護(hù)作用;選擇性抑制神經(jīng)元血紅素氧合酶-2基因的表達(dá)可減輕氧化應(yīng)激性組織細(xì)胞損傷. |
