| 產品編號 | bs-7606R-BF488 |
| 英文名稱1 | Rabbit Anti-CYFIP2/BF488 Conjugated antibody |
| 中文名稱 | BF488標記的細胞質脆性X智力低下蛋白結合蛋白2抗體 |
| 別 名 | CYFP2; cytoplasmic FMR1 interacting protein 2; KIAA1168; p53 inducible protein; p53-inducible protein 121; PIR121; CYFP2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領域 | 細胞生物 神經生物學 信號轉導 細胞凋亡 轉錄調節(jié)因子 t-淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, ) |
| 產品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 148kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYFIP2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產品介紹 |
background: CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing. Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA Subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Subcellular Location: Cytoplasm. Cytoplasm, perinuclear region. Cell junction , synapse, synaptosome. Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. Tissue Specificity: Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level). Similarity: Belongs to the CYFIP family. Database links: UniProtKB/Swiss-Prot: Q96F07.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脆性X綜合癥，又稱馬丁－貝爾綜合癥，是一種遺傳疾病。該綜合癥可以導致一系列的特征性癥狀，包括生理、智力、情緒、以及行為上的異常。癥狀的輕重各有不同。該疾病伴隨著X染色體上一個簡單的三核苷酸基因序列（CGG）的擴增。這種擴增導致了一種稱為FMR-1的蛋白質無法在病人體內表達，而該蛋白質是神經的正常發(fā)育必不可少的。 根據CGG重復序列的長度，目前普遍認可將脆性X綜合癥分為四種類型：正常人（含有19－31個CGG重復序列），前突變者（含有55－200個CGG重復序列），全突變者（含有200個以上的CGG重復序列），過渡型，又稱“灰色區(qū)域型”（含有40－60個重復）。脆性X綜合征這是一種導致智力低下的遺傳疾病，是導致人群中智力低下的第二大病因——僅次于21三體綜合癥。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
