| 產(chǎn)品編號 | bs-1177R-BF594 |
| 英文名稱1 | Rabbit Anti-Lingo-1/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的Nogo受體反應(yīng)蛋白抗體 |
| 別 名 | FLJ14594; LERN 1; LERN1; Lingo1; Leucine rich repeat and Ig domain containing 1; Leucine rich repeat neuronal protein 1; Leucine rich repeat neuronal protein 6A; Leucine-rich repeat neuronal 6A; Lingo 1; LRR and Ig domain-containing Nogo Receptor interating protein; Lrrn 6a; Lrrn6a; Lrrn6a protein; MGC17422; Nogo Receptor interacting protein; UNQ201. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 細(xì)胞膜受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Lingo-1 (521-620aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex. Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. Subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. Post-translational modifications: N-glycosylated. Contains predominantly high-mannose glycans. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 11 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 LRRNT domain Database links: Entrez Gene: 415344 Chicken Entrez Gene: 84894 Human Entrez Gene: 235402 Mouse Omim: 609791 Human SwissProt: Q50L44 Chicken SwissProt: Q6NUK3 Human SwissProt: Q96FE5 Human SwissProt: Q9D1T0 Mouse Unigene: 656765 Human Unigene: 246605 Mouse Unigene: 20269 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） LINGO-1是一種體內(nèi)體外少突膠質(zhì)細(xì)胞(Oligodendrocyte)分化和髓鞘(myelination)的負(fù)調(diào)控因子，神經(jīng)元上的LINGO-1被證明參與調(diào)節(jié)中樞神經(jīng)再生的抑制信號，而少突膠質(zhì)細(xì)胞表達(dá)的LINGO-1分子參與負(fù)調(diào)節(jié)少突膠質(zhì)細(xì)胞的髓鞘化過程，是一種體內(nèi)體外少突膠質(zhì)細(xì)胞(Oligodendrocyte)分化和髓鞘(myelination)的負(fù)調(diào)控因子。 |
