吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
欧美老熟妇又粗又大,亚洲无AV在线中文字幕
Rabbit Anti-PKM2/PE Conjugated antibody (bs-0101R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0101R-PE
英文名稱1 Rabbit Anti-PKM2/PE Conjugated antibody
中文名稱 PE標(biāo)記的丙酮酸激酶-M2抗體
別    名 PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PKM2; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3; KPYM_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  腫瘤細(xì)胞生物標(biāo)志物  新陳代謝  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PKM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Subunit:
Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate. Binding to certain oncoproteins such as HPV-16 E7 oncoprotein can trigger dimerization. FBP stimulates the formation of tetramers from dimers. Interacts with HERC1, POU5F1 and PML. Interacts (isoform M2) with EGLN3; the interaction hydroxylates PKM under hypoxia and enhances binding to HIF1A. Interacts (isoform M2) with HIF1A; the interaction is enhanced by binding of EGLN3, promoting enhanced transcription activity under hypoxia.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.

Tissue Specificity:
Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
ISGylated.
Under hypoxia, hydroxylated by EGLN3.

Similarity:
Belongs to the pyruvate kinase family.

Database links:

Entrez Gene: 5315 Human

Entrez Gene: 18746 Mouse

Entrez Gene: 25630 Rat

Omim: 179050 Human

SwissProt: P14618 Human

SwissProt: P52480 Mouse

SwissProt: P11980 Rat

Unigene: 534770 Human

Unigene: 326167 Mouse

Unigene: 405069 Mouse

Unigene: 1556 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

丙酮酸激酶(PK)有L、R、M1、M2四種同功酶,均為四聚體。
L型主要分布于肝臟,R型存在于紅細(xì)胞,在結(jié)構(gòu)、免疫學(xué)和動(dòng)力學(xué)上十分相似,由同一基因調(diào)控;M1存在于肌肉中,M2分布于除上述以外的其他組織(尤以腎臟最多)以及胎兒各組織。PK也是一種癌胚蛋白,在惡性腫瘤中,增高的都是M2型。

版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
熟妇人妻一区二区三区四区| 狠狠综合久久AV一区二区| 欧美又粗又大XXXXBBBB疯狂| 沈阳熟妇28厘米大战黑人| 亚洲AV无码精品色午夜果冻不卡| 人人妻人人藻人人爽欧美一区| 国产精品污WWW一区二区三区| 国产亚洲精品久久久久久禁果TV| 无码粉嫩虎白一线天在线观看| 欧美巨大另类极品videosbest| 久久久无码一区二区三区| 大肉大捧一进一出好爽视频| 一本久道综合色婷婷五月| 亚洲区小说区图片区QVOD| 老熟女草BX×| 久久久久SE色偷偷亚洲精品AV| 日韩精品一区二区三区色欲AV| 中文在线中文资源| 中文字幕被公侵犯的漂亮人妻| 香蕉久久夜色精品升级完成| 45分钟做受片免费观看| 爆乳熟妇一区二区三区| 色翁荡熄又大又硬又粗又视频| 99久久精品无码一区二区毛片| 小鲜肉吃小鲜肉的大LOGO| 人人妻人人澡人人爽精品日本| 我被脱个精光绑起来憋尿的作文| 精品呦啊呦V视频在线观看| 久久精品国产精品亚洲色婷婷| 亚洲精品亚洲人成人网| 亚洲精品久久久久久久观小说| 久久久久久亚洲精品| 97视频在线观看| 亚洲AV无码国产综合专区| 成人免费无码成人影院日韩| PORNO日本| 午夜天堂精品久久久久| 亚洲欧美日本韩国| 粗大的内捧猛烈进出| 国产99久久久国产精品免费看| 亚洲国产精品无码久久久秋霞1|