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Rabbit Anti-MAdCAM-1/Gold Conjugated antibody (bs-0642R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0642R-Gold
英文名稱1 Rabbit Anti-MAdCAM-1/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的粘膜血管定居因子抗體
別    名 Mucosal addressin cellular adhesion molecule-1; Addressin mucosal; hMAdCAM 1; MACAM1; Mucosal addressin cell adhesion molecule 1; Mucosal vascular addressin cell adhesion molecule 1; MADCA_RAT.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  心血管  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat MAdCAM-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function:
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity).

Subunit:
Homodimer (Probable).

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Detected in Peyer patches and mesenteric lymph nodes but not in spleen.

Similarity:
Contains 3 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 17123 Mouse

SwissProt: Q61826 Mouse

Unigene: 391556 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MAdCAM-1(粘膜血管定居因子或黏膜地址素細(xì)胞黏附分子)、CD44等均參與癌癥和腫瘤細(xì)胞與血管內(nèi)皮的相互作用,與癌癥和腫瘤細(xì)胞一起穿過血管內(nèi)皮而進(jìn)入血管內(nèi),參與血行播散轉(zhuǎn)移。
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