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Rabbit Anti-Megsin/APC Conjugated antibody (bs-0815R-APC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0815R-APC
英文名稱1 Rabbit Anti-Megsin/APC Conjugated antibody
中文名稱 APC標(biāo)記的絲氨酸蛋白酶抑制劑B7抗體
別    名 SER-PINB7; MEGSIN; Mesangium predominant gene megsin; MGC120014; MGC120015; Serpin B7; Serpin peptidase inhibitor clade B (ovalbumin) member 7; TP55; SPB7_HUMAN.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Megsin (295-330aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Serpin B7 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in a search for agents responsible for thrombopoiesis, and maturation of megakaryocytes. SerpinB7 was identified as a protein that increased acetylcholine esterase stimulation from bone barrow progenitor cells, and injection of SerpinB7 in mice induced a 40% increase in platelets compared to controls. Shortly thereafter, in a search for kidney specific genes, SerpinB7 was described as a protein specific to mesangial cells, and was named megsin to indicate the tissue specificity of the protein.

Function:
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Predominantly expressed in mesangial cells.

Similarity:
Belongs to the serpin family. Ov-serpin subfamily.

Database links:

Entrez Gene: 8710 Human

Omim: 603357 Human

SwissProt: O75635 Human

Unigene: 138202 Human

Unigene: 742388 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

megsin是新近發(fā)現(xiàn)的蛋白質(zhì),屬于絲氨酸蛋白酶抑制劑(Serpin)超家族,特異表達(dá)于腎小球系膜細(xì)胞,其表達(dá)異常在腎臟疾病進(jìn)展中具有重要作用,megsin蛋白適量的表達(dá),對(duì)維持人體正常的生理病理過(guò)程如凝血、纖維溶解、間質(zhì)代謝、發(fā)育、血壓、腫瘤和炎癥等是很重要的。在系膜細(xì)胞增生和系膜基質(zhì)增多明顯的IgA腎病腎小球中,megsin的表達(dá)顯著上調(diào)。
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