產(chǎn)品編號 | bs-0815R-BF555 |
英文名稱1 | Rabbit Anti-Megsin/BF555 Conjugated antibody |
中文名稱 | BF555標記的絲氨酸蛋白酶抑制劑B7抗體 |
別 名 | SER-PINB7; MEGSIN; Mesangium predominant gene megsin; MGC120014; MGC120015; Serpin B7; Serpin peptidase inhibitor clade B (ovalbumin) member 7; TP55; SPB7_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細胞生物 神經(jīng)生物學 信號轉(zhuǎn)導 細胞凋亡 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Rat, (predicted: Human, Mouse, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 42kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Megsin (295-330aa) |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Serpin B7 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in a search for agents responsible for thrombopoiesis, and maturation of megakaryocytes. SerpinB7 was identified as a protein that increased acetylcholine esterase stimulation from bone barrow progenitor cells, and injection of SerpinB7 in mice induced a 40% increase in platelets compared to controls. Shortly thereafter, in a search for kidney specific genes, SerpinB7 was described as a protein specific to mesangial cells, and was named megsin to indicate the tissue specificity of the protein. Function: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in mesangial cells. Similarity: Belongs to the serpin family. Ov-serpin subfamily. Database links: Entrez Gene: 8710 Human Omim: 603357 Human SwissProt: O75635 Human Unigene: 138202 Human Unigene: 742388 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. megsin是新近發(fā)現(xiàn)的蛋白質(zhì),屬于絲氨酸蛋白酶抑制劑(Serpin)超家族,特異表達于腎小球系膜細胞,其表達異常在腎臟疾病進展中具有重要作用,megsin蛋白適量的表達,對維持人體正常的生理病理過程如凝血、纖維溶解、間質(zhì)代謝、發(fā)育、血壓、腫瘤和炎癥等是很重要的。在系膜細胞增生和系膜基質(zhì)增多明顯的IgA腎病腎小球中,megsin的表達顯著上調(diào)。 |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關(guān)于肽鏈的設(shè)計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |