吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
娇妻被领导粗又大又硬,男男惩罚羞耻双腿分打屁股小作文 ,亚洲成AV人片在线观看无码
Rabbit Anti-Aggrecan1/RBITC Conjugated antibody (bs-1223R-RBITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1223R-RBITC
英文名稱(chēng)1 Rabbit Anti-Aggrecan1/RBITC Conjugated antibody
中文名稱(chēng) 羅丹明(RBITC)標(biāo)記的軟骨蛋白聚糖抗體
別    名 PGCA_HUMAN; ACAN; AGC 1; AGC1; AGCAN; Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal A0122); Aggrecan 1; Aggrecan core protein; Aggrecan proteoglycan; Aggrecan structural proteoglycan of cartilage; Aggrecan1; ATEGQV; Aggrecan ARGxx; Cartilage specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1 ; Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122; Chondroitin sulfate proteoglycan core protein 1; CSPG 1; CSPG1; CSPGCP; JSCATE; Large aggregating proteoglycan; MSK 16; MSK16; SEDK.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 208/248kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aggrecan
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

Function:
Aggrecan has been detected in neural precursor cells (neurospheres; Kabos et al, 2004) During differentiation, neurospheres downregulate Chondroitin sulfate proteoglycans (CSPGs). Proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation; suggesting a link between CSPGs and CNS precursor biology.

Subunit:
Interacts with FBLN1. Interacts with COMP.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Restricted to cartilages.

Post-translational modifications:
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

DISEASE:
Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Note=The disease is caused by mutations affecting the gene represented in this entry.
Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 4 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 403828 Dog

Entrez Gene: 176 Human

Entrez Gene: 11595 Mouse

Entrez Gene: 58968 Rat

Omim: 155760 Human

SwissProt: Q28343 Dog

SwissProt: P16112 Human

SwissProt: Q61282 Mouse

SwissProt: P07897 Rat

Unigene: 2159 Human

Unigene: 358571 Mouse

Unigene: 54503 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Aggrecan是軟骨細(xì)胞外基質(zhì)的主要結(jié)構(gòu)成分之一。它與膠原蛋白網(wǎng)絡(luò)結(jié)合,維持軟骨彈性、緩沖壓力,承擔(dān)負(fù)荷,并有自我潤(rùn)滑的性能。蛋白多糖的進(jìn)行性喪失是骨性關(guān)節(jié)病發(fā)病主要原因之一。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
一本色道久久88加勒比—综合| 欧美日本免费一区二区三区| 精品国产乱码久久久久久| 精品久久久久久无码中文字幕一区| 中文字幕人成无码人妻综合社区| 国产又黄又大又粗的视频| 吸咬奶头狂揉60分钟视频| 欧美无人区码SUV| 国产成人AV| 奶水H人妻销魂共妻高H| 亚洲精品久久久久AV无码| A级毛片无码久久精品免费| 99精品一区二区三区无码吞精| 久久人妻熟女一区二区| 少妇久久久久久久久久| 成熟护士长的蚌肉的滋味| 激情欧美日韩一区二区| 欧美大片VA欧美在线播放| 久久99精品久久久久久琪琪 | 亚洲AV无码乱码在线观看裸奔| 国产成人精品一区二区三区免费 | 久久久久亚洲AV无码专区喷水| 亚洲色大成网站WWW| 久久久亚洲精华液精华液精华液 | 人妻换人妻A片爽麻豆| 一边吃奶一边添P好爽故事| 精品欧美一区二区在线观看| 里番本子纯肉侵犯肉全彩无码| 亚洲AV无码国产精品色软件| 性XXXXX大片免费视频| 亚洲熟妇无码另类久久久| 波多野结衣网站| 欧美JIZZ18性欧美| 黑人大荫道BBWBBB高潮潮喷| 国产成人精品一区二区三区视频| 亚洲国产精品日韩AV不卡在线| 国产女人18毛片水真多18精品| 国产大人和孩做爰BD| 国产成人无码A区在线观看视频 | 国产乱子伦精品无码专区| 国产精品伦一区二区三级视频|