吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
自拍日韩亚洲一区在线,妓院一钑片免看黄大片,人妻少妇精品无码专区二区
Rabbit Anti-Aggrecan1/BF594 Conjugated antibody (bs-1223R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-1223R-BF594
英文名稱1 Rabbit Anti-Aggrecan1/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的軟骨蛋白聚糖抗體
別    名 PGCA_HUMAN; ACAN; AGC 1; AGC1; AGCAN; Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal A0122); Aggrecan 1; Aggrecan core protein; Aggrecan proteoglycan; Aggrecan structural proteoglycan of cartilage; Aggrecan1; ATEGQV; Aggrecan ARGxx; Cartilage specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1 ; Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122; Chondroitin sulfate proteoglycan core protein 1; CSPG 1; CSPG1; CSPGCP; JSCATE; Large aggregating proteoglycan; MSK 16; MSK16; SEDK.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 208/248kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aggrecan
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

Function:
Aggrecan has been detected in neural precursor cells (neurospheres; Kabos et al, 2004) During differentiation, neurospheres downregulate Chondroitin sulfate proteoglycans (CSPGs). Proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation; suggesting a link between CSPGs and CNS precursor biology.

Subunit:
Interacts with FBLN1. Interacts with COMP.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Restricted to cartilages.

Post-translational modifications:
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

DISEASE:
Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Note=The disease is caused by mutations affecting the gene represented in this entry.
Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 4 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 403828 Dog

Entrez Gene: 176 Human

Entrez Gene: 11595 Mouse

Entrez Gene: 58968 Rat

Omim: 155760 Human

SwissProt: Q28343 Dog

SwissProt: P16112 Human

SwissProt: Q61282 Mouse

SwissProt: P07897 Rat

Unigene: 2159 Human

Unigene: 358571 Mouse

Unigene: 54503 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Aggrecan是軟骨細(xì)胞外基質(zhì)的主要結(jié)構(gòu)成分之一。它與膠原蛋白網(wǎng)絡(luò)結(jié)合,維持軟骨彈性、緩沖壓力,承擔(dān)負(fù)荷,并有自我潤滑的性能。蛋白多糖的進(jìn)行性喪失是骨性關(guān)節(jié)病發(fā)病主要原因之一。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲精品无码久久久久久久| 97成人无码免费一区二区中文| 久久夜色精品国产| 乱人伦人妻精品一区二区| 久久精品| 欧美疯狂做受XXXXX高潮| 真实的国产乱XXXX在线| 久久亚洲AV无码西西人体| 公和我做好爽添厨房在线观看| 国产乡下三级全黄三级bd| 久久午夜无码鲁丝片| 久久久久99精品成人片直播 | 欧美又色又爽又黄的A片18禁| 国产精品情侣呻吟对白视频| 国产精品久久久久无码AV| 午夜时刻免费入口| 高清家庭影院| 97在线视频人妻无码| 粉嫩av国产一区二区三区| 亚洲18色成人网站WWW| 久久97精品久久久久久久不卡| 亚洲视频一区| 国产在线视频一区二区三区| 国产精品扒开腿做爽爽爽A片小说 亚洲AV无码乱码在线观看性色 | 欧美人与物videos另类| 嫩草伊人久久精品少妇AV网站| 国产无遮挡又黄又爽在线观看| 色视频WWW在线播放国产人成 | 亚洲无AV在线中文字幕| 国产精品videossex国产高清 | 免费60分钟床| 国产日产亚洲系列最新| 精品久久久久久综合日本| 精人妻无码一区二区三区| 久久无码专区国产精品S| 国产精品伦一区二区三级视频| 公和我在野外做好爽爱爱小说雨婷| 国产亚洲精品久久久无码| 人人妻人人澡人人爽| 国产人妻大战黑人20P| 性色AV无码不卡中文字幕|