| 產(chǎn)品編號 | bs-0071R-AP |
| 英文名稱1 | Rabbit Anti-Neuropeptide Y/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的神經(jīng)肽Y抗體 |
| 別 名 | Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; Pro-neuropeptide Y; NPY_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4/8kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NPY |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Subcellular Location: Secreted. Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. Post-translational modifications: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Similarity: Belongs to the NPY family. Database links: Entrez Gene: 396464 Chicken Entrez Gene: 4852 Human Entrez Gene: 109648 Mouse Omim: 162640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白 神經(jīng)肽Y是一種神經(jīng)傳導(dǎo)因子，參與機(jī)體的應(yīng)急反應(yīng)， 在應(yīng)激狀態(tài)下-NPY升高;他還可以促進(jìn)血小板聚集、白細(xì)胞粘附及 巨噬細(xì)胞活化而參 與免疫反應(yīng) 神經(jīng)肽Y廣泛分布于動物中樞和外周神經(jīng)元及機(jī)體組織、器官和腺體內(nèi) ,影響動物采食、激素分泌、心血管效應(yīng)、調(diào)節(jié)體溫、生物節(jié)律、性行為及動物情緒等多種功能。 由于結(jié)構(gòu)中富含酪氨酸 ,故稱為神經(jīng)肽酪氨酸 (NPY)。它的結(jié)構(gòu)與同是 36個氨基酸的胰多肽 (pp)和肽 YY(PYY)極其相似 ,故認(rèn)為同屬胰多肽家族。從分子結(jié)構(gòu)看 ,人、大鼠、豚鼠和兔序列安全一致 ,而牛、羊、豬 NPY序列與人的序列只相差一個氨基酸。 |
