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Rabbit Anti-Orexin receptor 1+2/RBITC Conjugated antibody (bs-1095R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1095R-RBITC
英文名稱1 Rabbit Anti-Orexin receptor 1+2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的丘腦分泌素受體1+2/食欲素受體1+2抗體
別    名 Orexin Receptor 1 and 2; Orexin receptor 1 + 2; Orexin Receptor 2; HCRTR 1; HCRTR1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1r; OX1R_HUMAN; Hcrtr2; Hypocretin (orexin) receptor 2; Hypocretin receptor 2; Hypocretin receptor type 2; Orexin receptor 2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2r; OX2R_HUMAN.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  細(xì)胞膜受體  內(nèi)分泌病  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Orexin receptor 1/2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

Function:
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 3061 Human

Entrez Gene: 230777 Mouse

Entrez Gene: 25593 Rat

Omim: 602392 Human

SwissProt: O43613 Human

SwissProt: P58307 Mouse

SwissProt: P56718 Rat

Unigene: 388226 Human

Unigene: 246595 Mouse

Unigene: 88262 Rat

Entrez Gene: 3062 Human

Entrez Gene: 387285 Mouse

Entrez Gene: 25605 Rat

Omim: 602393 Human

SwissProt: O43614 Human

SwissProt: P58308 Mouse

SwissProt: P56719 Rat

Unigene: 151624 Human

Unigene: 699147 Human

Unigene: 335300 Mouse

Unigene: 9893 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

食欲素受體(OXR)Orexin receptor—是一種G蛋白偶合受體. 下丘腦是調(diào)節(jié)飲食及能量平衡的中樞.學(xué)者認(rèn)為:在下丘腦可促進(jìn)食欲且來源于同一前體的兩種新神經(jīng)肽:食欲素A和B,它們可激活兩種密切相關(guān)且與G蛋白偶聯(lián)的細(xì)胞表面受體(OX1R,OX2R).含Orexin的神經(jīng)細(xì)胞在下丘腦腹外側(cè)呈對(duì)稱的不連貫分布. 在飲食反饋調(diào)節(jié)中具有重要作用.食欲素與其它影響進(jìn)食的神經(jīng)肽之間存在錯(cuò)綜復(fù)雜的關(guān)系.它在增加攝食、飲水、調(diào)節(jié)睡眠覺醒周期、生殖、體溫、血壓和感覺等方面有廣泛作用.
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