吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
人妻体内射精一区二区三区,一区二区三区视频,潘金莲被武松高潮八次小说
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-CDKN2A/p16-INK4a/Cy5 Conjugated antibody (bs-0740R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0740R-Cy5
英文名稱1 Rabbit Anti-CDKN2A/p16-INK4a/Cy5 Conjugated antibody
中文名稱 Cy5標記的抑癌基因p16抗體
別    名 cyclin-dependent kinase inhibitor 2A; CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  信號轉(zhuǎn)導  細胞凋亡  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Pig, )
產(chǎn)品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human P16
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].

Function:
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Subunit:
Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts (isoforms 1,2 and 4) with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

DISEASE:
Note=The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.
Defects in CDKN2A are the cause of cutaneous malignant melanoma type 2 (CMM2) [MIM:155601]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome (FAMMMPC) [MIM:606719].
Defects in CDKN2A are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. [DISEASE] Defects in CDKN2A are the cause of melanoma-astrocytoma syndrome (MASTS) [MIM:155755]. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.

Database links:

Entrez Gene: 1029 Human

Entrez Gene: 12578 Mouse

Entrez Gene: 25163 Rat

Omim: 600160 Human

SwissProt: P42771 Human

SwissProt: P51480 Mouse

SwissProt: Q9R0Z3 Rat

Unigene: 512599 Human

Unigene: 4733 Mouse

Unigene: 48717 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞周期失控是癌變的重要原因。p16是近年來發(fā)現(xiàn)的第一個直接參與細胞周期調(diào)控的抑癌基因,其表達產(chǎn)物為p16蛋白.
p16基因是一種重要的抑癌基因,在正常細胞中起負反饋作用,當p16基因突變或丟失時,細胞增殖失去控制使細胞無限制地增殖。
p16主要功能是通過抑制CDK4而阻止細胞由G1期進入S期,使細胞增殖受到限制。用于各種惡性腫瘤如肺癌、惡黑、乳腺癌的研究。目前的研究細胞周期依賴激酶抑制p16INK4a蛋白在宮頸上皮內(nèi)病變(CIN)中作為一個新標記物.
p16INK4a的過表達與HPV E7區(qū)(病毒早期蛋白即病毒致癌基因編碼區(qū))活性有密切相關(guān)性。
p16/CDKN2基因是新近發(fā)現(xiàn)的腫瘤抑制基因,已有研究表明該基因在許多腫瘤出現(xiàn)缺失、突變或重排現(xiàn)象.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日本护士毛茸茸高潮| 久久国产精久久精产国| 精品无人区一区二区三区| 99久久久无码国产精品性| 一本色道无码道DVD在线观看| 无套熟女AV呻吟在线观看| 亚洲国产精品无码成人片久久| 日韩亚洲AV人人夜夜澡人人爽| 国产精品乱码一区二区三区| 免费三级网站| 亚洲中文字幕无码AV| 国产大片B站免费观看推荐| 极品少妇xxxx精品少妇偷拍| 孕妇滴着奶水做着爱A| 久久精品99国产精品日本| 亚洲AV无一区二区三区久久| 免费男人下部进女人下部视频| 色综合久久网| 99精品国产一区二区| 人妻少妇AV中文字幕乱码| 人妻丰满熟妇AV无码区乱| 中国白嫩丰满人妻VIDEOS| 国产又黄又大又粗的视频| 亚洲精品一区中文字幕乱码| 一区二区乱子伦在线播放| 自拍偷在线精品自拍偷无码专区| 无码精品人妻一区二区三区人妻斩| 欧美XXXX黑人又粗又长精品| 暖暖爱视频免费| 日韩精品无码一区二区三区不卡 | 免费观看电视剧全集在线播放| 东北浓毛老妇国语对白| 亚洲 精品 综合 精品 自拍| 故意穿暴露被强好爽H漫画| 欧美午夜精品久久久久免费视 | 久久久GOGO无码啪啪艺术 | 妻子4免费完整版中文版 | 亚洲精品一区久久久久久| 风流少妇又紧又爽又丰满| 最残忍最另类残虐SM的小说| 被公牛日到了高潮|