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Rabbit Anti-Thrombin receptor/ PAR1/AP Conjugated antibody (bs-0828R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0828R-AP
英文名稱1 Rabbit Anti-Thrombin receptor/ PAR1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的蛋白酶激活受體-1抗體
別    名 SAR; BXR; Proteinase-activated receptor 1 precursor; Thrombin receptor; Coagulation factor II receptor; D15S227E; Prader-Willi/Angelman region-1; PAR1; Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Thrombin receptor; TR; PAR-1; Coagulation factor II receptor; Coagulation factor II receptor; PAR-1; PAR1_HUMAN; Proteinase activated receptor 1; Proteinase-activated receptor 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PAR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Platelets and vascular endothelial cells.

Post-translational modifications:
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 2149 Human

Omim: 187930 Human

SwissProt: P56488 Baboon

SwissProt: P25116 Human

Unigene: 482562 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PAR蛋白全稱為蛋白酶體活化受體(Protease-activated receptors),又稱:凝血酶受體(Thrombin Receptor)是獨立家族的G蛋白偶聯(lián)受體, 研究認(rèn)為與炎癥,實體腫瘤等密切相關(guān)。
PAR1蛋白是乳腺癌細(xì)胞侵潤和遷移的必需因子,它是作為基質(zhì)金屬蛋白酶體1(MMP-1)的受體關(guān)鍵性作用,這一研究結(jié)果為研制新的抗癌藥物提供新的靶點。
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