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Rabbit Anti-PLGF/RBITC Conjugated antibody (bs-0280R-RBITC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0280R-RBITC
英文名稱1 Rabbit Anti-PLGF/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的胎盤生長(zhǎng)因子抗體
別    名 Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse PLGF
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.

Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

Database links:

Entrez Gene: 5228 Human

Entrez Gene: 18654 Mouse

Entrez Gene: 94203 Rat

Omim: 601121 Human

SwissProt: P49763 Human

SwissProt: P49764 Mouse

SwissProt: Q63434 Rat

Unigene: 252820 Human

Unigene: 4809 Mouse

Unigene: 6960 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PLGF胎盤生長(zhǎng)因子是血管生長(zhǎng)因子家族成員之一(又稱:胎盤型血管內(nèi)皮細(xì)胞生長(zhǎng)因子),是動(dòng)脈粥樣硬化斑塊不穩(wěn)定的主要炎性激活物,因此它可作為ACS患者風(fēng)險(xiǎn)預(yù)測(cè)的生物學(xué)標(biāo)志物.尿胎盤生長(zhǎng)因子水平可預(yù)測(cè)先兆子癇危險(xiǎn).研究人員發(fā)現(xiàn),在疾病發(fā)作前的6到8周,先兆子癇患者尿液中的胎盤生長(zhǎng)因子水平急劇下降,這種新的尿檢方法使提前1到2個(gè)月預(yù)測(cè)先兆子癇成為可能。亦有研究人員正在從事胎盤生長(zhǎng)因子與肺氣腫,胃癌,腸癌等方面的研究。
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