| 產(chǎn)品編號 | bs-0417R-BF488 |
| 英文名稱1 | Rabbit Anti-TIMP-3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的金屬蛋白酶組織抑制因子-3抗體 |
| 別 名 | HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 合成與降解 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIMP-3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. Subunit: Interacts with EFEMP1. Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. Database links: Entrez Gene: 7078 Human Entrez Gene: 21859 Mouse Omim: 188826 Human SwissProt: P35625 Human SwissProt: P39876 Mouse Unigene: 644633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） 近年來，國內(nèi)外科研人員對TIMP-3的抗腫瘤作用日益被重視，學(xué)者認(rèn)為：TIMP-3具有強(qiáng)烈促凋亡、抑制血管生成、抗腫瘤浸潤作用，TIMP-3與TIMP-1、2且相互間有明顯協(xié)同抗腫瘤作用 |
