| 產(chǎn)品編號(hào) | bs-0716R-BF488 |
| 英文名稱1 | Rabbit Anti-CIDEB/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的CIDEB抗體 |
| 別 名 | cell death activator CIDE-B; Cell death activator CIDE B; Cell death inducing DFFA like effector B; CIDEB_HUMAN; cell death-inducing DFFA-like effector B; Cide-b. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞凋亡 細(xì)胞周期蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CIDEB (115-160aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow. Function: Activates apoptosis. Subunit: Inhibited by DFFB. Interacts with DFFA and DFFB. Tissue Specificity: Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Similarity: Contains 1 CIDE-N domain. Database links: Entrez Gene: 27141 Human Entrez Gene: 12684 Mouse Omim: 604441 Human SwissProt: Q546V8 Human SwissProt: Q9UHD4 Human SwissProt: O70303 Mouse Unigene: 642693 Human Unigene: 696081 Human Unigene: 708040 Human Unigene: 466766 Mouse Unigene: 204016 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CIDEB是在細(xì)胞凋亡的過程中誘導(dǎo)分泌的一種蛋白，在棕色脂肪組織，肝臟和腎臟中發(fā)現(xiàn)有高水平的DFF45-like effector--DFF45樣效應(yīng)子b蛋白，簡(jiǎn)稱cideb。CIDEB具有調(diào)控脂質(zhì)代謝的作用。 |
