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Rabbit Anti-G6PDH/HRP Conjugated antibody (bs-6989R-HRP)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-6989R-HRP
英文名稱(chēng)1 Rabbit Anti-G6PDH/HRP Conjugated antibody
中文名稱(chēng) 辣根過(guò)氧化物酶標(biāo)記的己糖6磷酸脫氫酶抗體
別    名 6 phosphogluconolactonase; 6-phosphogluconolactonase; 6PGL; H6PD; DKFZp686A01246; G6PD H form; G6PDH; G6PE_HUMAN; GDH; H6PD; GDH/6PGL endoplasmic bifunctional protein; Glucose 1 dehydrogenase; Glucose 6 phosphate dehydrogenase salivary; Glucose dehyrogenase; Gpd1; H6pd; Hexose 6 phosphate dehydrogenase; Hexose-6-phosphate dehydrogenase; MGC87643.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G6PDH
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone).

Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.

Subcellular Location:
Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen.

Tissue Specificity:
Present in most tissues examined, strongest in liver.

DISEASE:
Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

Similarity:
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Database links:

Entrez Gene: 25796 Human

Entrez Gene: 9563 Human

Entrez Gene: 100198 Mouse

Entrez Gene: 66171 Mouse

Entrez Gene: 290636 Rat

Entrez Gene: 298655 Rat

Omim: 138090 Human

Omim: 604951 Human

SwissProt: O95336 Human

SwissProt: O95479 Human

SwissProt: Q8CFX1 Mouse

SwissProt: Q9CQ60 Mouse

SwissProt: P85971 Rat

Unigene: 463511 Human

Unigene: 466165 Human

Unigene: 22183 Mouse

Unigene: 282284 Mouse

Unigene: 402679 Mouse

Unigene: 17292 Rat

Unigene: 19855 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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