吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
国产成人精品三级麻豆,国产男女无遮挡猛进猛出,亚洲精品久久久久久
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CBL2/BF555 Conjugated antibody (bs-5147R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5147R-BF555
英文名稱1 Rabbit Anti-CBL2/BF555 Conjugated antibody
中文名稱 BF555標記的原癌基因CBL2抗體
別    名 C CBL; CBL C; Cas Br M (murine) ecotropic retroviral transforming sequence; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; Casitas B-lineage lymphoma proto-oncogene; CBL 2; cbl; CBL_HUMAN; CBL2; E3 ubiquitin protein ligase CBL; E3 ubiquitin-protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; Proto-oncogene c-CBL; RGD1561386; RING finger protein 55; RNF55; Signal transduction protein CBL.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  染色質和核信號  信號轉導  細胞凋亡  生長因子和激素  轉錄調節(jié)因子  細胞膜受體  b-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C CBL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Function:
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Subunit:
Interacts (phosphorylated at Tyr-731) with PIK3R1. Associates with NCK via its SH3 domain.

Subcellular Location:
Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.

DISEASE:
Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) [MIM:613563]. A syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects.

Similarity:
Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
Contains 1 RING-type zinc finger.
Contains 1 UBA domain.

Database links:

Entrez Gene: 867 Human

Entrez Gene: 12402 Mouse

Entrez Gene: 500985 Rat

Omim: 165360 Human

SwissProt: P22681 Human

SwissProt: P22682 Mouse

Unigene: 504096 Human

Unigene: 266871 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

C CBL是泛素一蛋白酶體(ubiquitin proteasome)通路中的一個新的RINGFinger型泛素連接酶(ubiquitinligase ,E3).C CBL可以介導受體酪氨酸激酶和非受體酪氨酸受體激酶的降解.
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
未满十八18禁止免费无码网站| 麻豆一区二区99久久久久| 人妻少妇一区二区三区| 中文字幕人妻色偷偷久久| 免费A级毛片黄A片高清在线播放 | 国产成人无码综合亚洲日韩| 麻豆国产AV超爽剧情系列| 纯爱无遮挡H肉动漫在线播放| 乱码丰满人妻一二三区| 欧美性大战久久久久久久| 纤夫的爱在线观看完整版动漫| 免费av在线| 亚洲中文字幕无码爆乳AV久久| 国产精品久久久久久爽爽爽床戏| 欧美日韩欧美| 色翁荡熄又大又硬又粗又视频| 美女脱了内裤张开腿让男人桶网站| 毛片免费视频| 精品国产污污免费网站AⅤ| 久久精品国产一区二区电影| 国产精品99久久久久久人| 无码精品一区二区三区在线| 精品无码三级在线观看视频| 女人高潮被爽到呻吟在线观看| 99精品国产在热久久婷婷| 巨大黑人极品VIDEOS精品| 久久黄色视频| 国产又色又爽又黄又免费| 久久久久亚洲精品无码网址 | 欲妇荡岳丰满少妇A片24小时| 欧美变态口味重另类在线视频 | 肥嫩多毛的大荫户| 白嫩少妇激情无码| WWW亚洲精品少妇裸乳一区二区| 一边摸一边做爽的视频17国产| 久久99精品久久久久子伦| 欧美变态口味重另类在线视频| 亚洲精品无码专区| 亚洲 欧美 叧类人妖| 久久久久亚洲AV成人网人人软件 | 无码人妻熟妇AV又粗又大|