吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
久久午夜无码鲁丝片午夜精品 ,久久久久99精品成人片,好色先生下载
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Girdin/BF647 Conjugated antibody (bs-5150R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5150R-BF647
英文名稱1 Rabbit Anti-Girdin/BF647 Conjugated antibody
中文名稱 BF647標記的肌動蛋白結合蛋白Girdin抗體
別    名 Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212; GIV.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  神經(jīng)生物學  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 206kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APE/Girdin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Subunit:
Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI(4)P] and weakly with phosphatidylinositol 3-phosphate [PI(3)P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.

Subcellular Location:
Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.

Tissue Specificity:
Expressed ubiquitously.

Post-translational modifications:
Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.

Similarity:
Belongs to the CCDC88 family.

Database links:

Entrez Gene: 55704 Human

Entrez Gene: 108686 Mouse

Entrez Gene: 305605 Rat

Omim: 609736 Human

SwissProt: Q3V6T2 Human

SwissProt: Q5SNZ0 Mouse

Unigene: 292925 Human

Unigene: 338284 Mouse

Unigene: 441367 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Girdin蛋白是一種新發(fā)現(xiàn)的肌動蛋白結合蛋白,能與Akt相互作用,在促進細胞的遷移及血管生成等方面具有重要作用,也是腫瘤發(fā)生、發(fā)展、腫瘤細胞運動等病理過程中的重要步驟和關鍵環(huán)節(jié).
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
AV无码精品一区二区三区| 人妻在卧室被老板疯狂进入| 日韩人妻无码一区二区三区| 色橹橹欧美在线观看视频高清| 国产精品久久久一区二区三区| 国产九九九九九九九A片| 6080YYY午夜理论AA片| A片扒开双腿进入做爽爽| 日韩亚洲AV人人夜夜澡人人爽| 亚洲人成无码WWW久久久| 亚洲欧美日韩在线不卡| 中文字幕一区二区三区日韩精品 | 拔萝卜视频免费观看高清下载 | 性XXXX18精品A片一区二区| H高潮娇喘抽搐A片国产麻豆| 欧美人妻日韩精品| 国产女主播喷水视频在线观看| 亚洲熟妇无码八AV在线播放| 特黄AAAAAAA片免费视频| 亚洲AV无码成人精品区在线观看| 全黄H全肉禁乱公| 一本久道中文无码字幕AV | 久久国产精品-国产精品| 中文字幕人妻女友一区蜜芽视频 | 黑人上司粗大拔不出来电影 | 国产又黄又爽又猛免费视频播放| 私人影院播放器| 久久精品国产亚洲AV久| 被C哭着爬走又被拉回来挺进H| 欧洲高清视频在线观看| 高潮毛片无遮挡高清免费| 欲妇荡岳丰满少妇A片24小时| 免费观看黄色电影| 久久久久久久97| 国产激情精品一区二区三区| 麻豆国产精品色欲AV亚洲三区 | 婷婷人人爽人人爽人人片| 人妻无码久久一区二区三区免费| 狂野欧美性猛交免费视频| 免费做爰试看120秒| 暖暖爱视频免费|