吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产白嫩护士被弄高潮,人妻精油按摩BD高清中文字幕 ,jizz日本
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Girdin/PE-Cy5.5 Conjugated antibody (bs-5150R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5150R-PE-Cy5.5
英文名稱1 Rabbit Anti-Girdin/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的肌動蛋白結(jié)合蛋白Girdin抗體
別    名 Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212; GIV.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 206kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APE/Girdin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Subunit:
Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI(4)P] and weakly with phosphatidylinositol 3-phosphate [PI(3)P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.

Subcellular Location:
Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.

Tissue Specificity:
Expressed ubiquitously.

Post-translational modifications:
Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.

Similarity:
Belongs to the CCDC88 family.

Database links:

Entrez Gene: 55704 Human

Entrez Gene: 108686 Mouse

Entrez Gene: 305605 Rat

Omim: 609736 Human

SwissProt: Q3V6T2 Human

SwissProt: Q5SNZ0 Mouse

Unigene: 292925 Human

Unigene: 338284 Mouse

Unigene: 441367 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Girdin蛋白是一種新發(fā)現(xiàn)的肌動蛋白結(jié)合蛋白,能與Akt相互作用,在促進細胞的遷移及血管生成等方面具有重要作用,也是腫瘤發(fā)生、發(fā)展、腫瘤細胞運動等病理過程中的重要步驟和關(guān)鍵環(huán)節(jié).
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久精品99国产精品日本 | 中文在线中文资源| 亚洲尺码与欧洲尺码区别入口跳转| 久久久久人妻一区精品色欧美 | 我强行与岳的性关系| 亚洲AV成人片无码网站网| 2022最新韩国理伦片在线观看| 大屁股熟女一区二区三区| 日韩视频在线观看| 公交车被cao到合不拢腿| 日本55丰满熟妇厨房伦| 97精品国产一区二区三区| 天天做天天爱夜夜爽| 极品少妇XXXX精品少妇偷拍| 极品少妇被猛得白浆直流草莓视频| 午夜福利视频| 国产+高潮+白浆+无码| 小12箩利洗澡无码视频网站| 国内精品一区二区三区| 国产精品污WWW在线观看| 无码欧精品亚洲日韩一区| 五月丁香综合啪啪成人小说| 上司人妻互换HD无码中文字幕| 嗯灬啊灬把腿张开灬A片| 精品白嫩BBWBBWBBW| (无码视频)在线观看| 亚洲AV无码专区在线播放中文| JAPAN少妇洗澡VIDEOS| 午夜福利理论片在线观看| 国产乱子伦一区二区三区| 丁香花在线观看免费观看图片 | 色一情一乱一伦一区二区三区日本 | 高清家庭影院| JAPANESEHD熟女熟妇| 亚洲毛片| 亚洲精品AV中文字幕在线| 亚洲AV毛片一区二区三区| 小箩莉末发育娇小性色XXXX| 国产人妻久久精品二区三区特黄| 国产精品久久久一区二区三区| 婷婷丁香五月|