| 產(chǎn)品編號 | bs-0077R-BF555 |
| 英文名稱1 | Rabbit Anti-VIP/BF555 Conjugated antibody |
| 中文名稱 | BF555標(biāo)記的血管活性腸肽抗體 |
| 別 名 | Vasoactive Intestinal peptide; MGC13587; Peptide histidine methioninamide 27; PHM 27; PHM27; PHV42; VIP peptides precursor; PHI; Peptide Histidine Isoleucine; Vasoactive intestinal peptide; VIP_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 3.3/18kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VIP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Growth Factor and Hormones VIP(Vasoactive Intestinal peptide) is a 28-amino acid peptide structurally related tosecretin. It was originally isolated from intestinal extracts and shown to be a potent vasodilator. Subsequent work demonstrated that VIP is very widely distributed in the peripheral and central nervous systems, and probably should not be considered a true GI hormone. A huge number of biological effects have been attributed to VIP. With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen. Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. PHM and PHV also cause vasodilation. Subcellular Location: Secreted. Similarity: Belongs to the glucagon family. Database links: Entrez Gene: 7432 Human Entrez Gene: 22353 Mouse Omim: 192320 Human SwissProt: P01282 Human SwissProt: P32648 Mouse Unigene: 53973 Human Unigene: 98916 Mouse Unigene: 18675 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. VIP是一個廣泛分布于中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)的神經(jīng)肽，他有較強(qiáng)的血管舒張作用、支氣管擴(kuò)張作用、平滑肌松弛作用，具有很多免疫系統(tǒng)細(xì)胞的活性，是一個促分裂劑。 近年來研究表明，VIP也是一種生長因子,它對多種惡性腫瘤的發(fā)生、發(fā)展、增殖和分化起重要的促進(jìn)作用，血管活性腸肽的神經(jīng)保護(hù)作用受到來自膠質(zhì)細(xì)胞的活性依賴的神經(jīng)營養(yǎng)因子釋放的調(diào)節(jié)。VIP和PACAP有很高的同源性。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation: VIP/AF555 Antibody, conjugated (bs-0077R-BF555) at 1:200 overnight at 4°C; DAPI (5ug/ml, blue, C-0033) was used to stain the cell nuclei.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation: VIP/AF555 Antibody, conjugated (bs-0077R-BF555) at 1:200 overnight at 4°C; DAPI (5ug/ml, blue, C-0033) was used to stain the cell nuclei.
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