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Rabbit Anti-VIP/PE-Cy7 Conjugated antibody (bs-0077R-PE-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0077R-PE-Cy7
英文名稱1 Rabbit Anti-VIP/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的血管活性腸肽抗體
別    名 Vasoactive Intestinal peptide; MGC13587; Peptide histidine methioninamide 27; PHM 27; PHM27; PHV42; VIP peptides precursor; PHI; Peptide Histidine Isoleucine; Vasoactive intestinal peptide; VIP_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3.3/18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VIP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Growth Factor and Hormones
VIP(Vasoactive Intestinal peptide) is a 28-amino acid peptide structurally related tosecretin. It was originally isolated from intestinal extracts and shown to be a potent vasodilator. Subsequent work demonstrated that VIP is very widely distributed in the peripheral and central nervous systems, and probably should not be considered a true GI hormone. A huge number of biological effects have been attributed to VIP. With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen.

Function:
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation.

Subcellular Location:
Secreted.

Similarity:
Belongs to the glucagon family.

Database links:

Entrez Gene: 7432 Human

Entrez Gene: 22353 Mouse

Entrez Gene: 117064 Rat

Omim: 192320 Human

SwissProt: P01282 Human

SwissProt: P32648 Mouse

SwissProt: P01283 Rat

Unigene: 53973 Human

Unigene: 98916 Mouse

Unigene: 18675 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

VIP是一個(gè)廣泛分布于中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)的神經(jīng)肽,他有較強(qiáng)的血管舒張作用、支氣管擴(kuò)張作用、平滑肌松弛作用,具有很多免疫系統(tǒng)細(xì)胞的活性,是一個(gè)促分裂劑。
近年來研究表明,VIP也是一種生長因子,它對(duì)多種惡性腫瘤的發(fā)生、發(fā)展、增殖和分化起重要的促進(jìn)作用,血管活性腸肽的神經(jīng)保護(hù)作用受到來自膠質(zhì)細(xì)胞的活性依賴的神經(jīng)營養(yǎng)因子釋放的調(diào)節(jié)。VIP和PACAP有很高的同源性。
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