吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
日韩一区二区三区精品,公与淑婷厨房猛烈进出视频韩国,色哟哟网站在线观看
Rabbit Anti-phospho-CTNNA1 (Ser641)/FITC Conjugated antibody (bs-5280R-FITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5280R-FITC
英文名稱1 Rabbit Anti-phospho-CTNNA1 (Ser641)/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的磷酸化α-連環(huán)蛋白抗體
別    名 p-CTNNA1 (Ser641); CTNNA1 (phospho-Ser641); CTNNA1 (phospho-S641); alpha 1 Catenin (phospho S641); alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; Alpha-cats; FLJ36832; NY REN 13 antigen; CTNA1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CTNNA1 around the phosphorylation site of Ser641 [DD(p-S)DF]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Function:
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Subunit:
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:
Expressed ubiquitously in normal tissues.

Post-translational modifications:
Sumoylated.

Similarity:
Belongs to the vinculin/alpha-catenin family.

Database links:

Entrez Gene: 1495 Human

Entrez Gene: 12385 Mouse

Entrez Gene: 307505 Rat

Omim: 116805 Human

SwissProt: P35221 Human

SwissProt: P26231 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

α-catenin是一種多功能的蛋白質(zhì),能鏈接E-\N-\P-鈣粘附分子,具有參與細(xì)胞粘附和介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)的雙重功能,并與腫瘤的發(fā)生發(fā)展及浸潤(rùn)密切相關(guān)。 在正常個(gè)體中,βα-catenin和鈣黏蛋白形成復(fù)合體,介導(dǎo)同型細(xì)胞的粘附,維持細(xì)胞的穩(wěn)定;同時(shí),α-catenin作為Wnt/α-catenin信號(hào)通路的關(guān)鍵成員在介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中調(diào)控細(xì)胞的增殖和凋亡。 在惡性腫瘤中,α-catenin的表達(dá)呈現(xiàn)明顯的異質(zhì)性,促使細(xì)胞異常增殖,還可使細(xì)胞之間的黏附性減弱,侵襲性增強(qiáng)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日本VA欧美VA精品发布| japanese老熟妇乱子伦视频| 亚洲AV无码国产精品永久一区| 亚洲av无码一区二区二三区| 韩国精品一区二区三区无码视频| 亚洲AV片不卡无码久久| 国产免费AV片无码永久免费| 凸凹人妻人人澡人人添| 人人妻人人澡人人爽欧美一区| 无码免费人妻A片AAA毛片一区| 亚洲AV乱码一区二区三区林ゆな | 久久精品AⅤ无码中文字字| 妽妽用身体满足了我| 日韩精品一区二区三区在线观看| 美女视频黄是免费| 无码人妻少妇色欲AV一区二区| 精品午夜福利在线观看| 日本a√在线观看| 午夜福利视频| 粉嫩XB粉嫩XB粉嫩XB| 国产在线精品二区| 校草喝下春药被男生玩弄| 日韩乱码人妻无码系列中文字幕| 精品无码一区二区三区爱欲| 日本亲近相奷中文字幕| 特级毛片爽WWW免费版| T66Y最新地址一地址二地址三| 久久精品中文字幕| 亚洲国产精品一区二区久久HS| 人妻少妇精品中文字幕AV蜜桃| 国产精品久久毛片| 狠狠色综合网站久久久久久久| 大乳丰满人妻中文字幕日本| 国产女人AAA级久久久级| 粉嫩XB粉嫩XB粉嫩XB| 女厕偷窥一区二区三区| 亚洲AV无码一区二区二三区软件| 张柏芝做爰全过程视频| 飘雪在线影院观看免费完整版高清| 欧美老妇交乱视频在线观看 | 无码人妻精品一区二区三区东京热|