吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
青青草原精品99久久精品66,女人扒开屁股桶爽30分钟
Rabbit Anti-phospho-Dnmt1(Ser154)/BF555 Conjugated antibody (bs-5294R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5294R-BF555
英文名稱1 Rabbit Anti-phospho-Dnmt1(Ser154)/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的磷酸化DNA甲基轉(zhuǎn)移酶1抗體
別    名 Dnmt1(phospho S154); Dnmt1 (phospho Ser154); p-Dnmt1 (Ser154); AIM; CXXC finger protein 9; CXXC-type zinc finger protein 9; CXXC9; DNA (cytosine 5 ) methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase M.HsaI.; DNA MTase; DNA MTase HsaI; DNMT 1; DNMT; Dnmt1; Dnmt1; DNMT1_HUMAN; Dnmt1o; FLJ16293; HSN1E; M.HsaI; MCMT; Met1; MGC104992; mMmul; MommeD2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 178kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Dnmt1 around the phosphorylation site of Ser153
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Subunit:
Binds to CSNK1D (By similarity). Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.

Post-translational modifications:
Sumoylated; sumoylation increases activity.
Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity.
Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability.
Methylation at Lys-142 by SETD7 promotes DNMT1 proteasomal degradation.

DISEASE:
Defects in DNMT1 are the cause of hereditary sensory neuropathy type 1E (HSN1E) [MIM:614116]. A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.

Similarity:
Belongs to the C5-methyltransferase family.
Contains 2 BAH domains.
Contains 1 CXXC-type zinc finger.

Database links:

Entrez Gene: 281119 Cow

Entrez Gene: 1786 Human

Entrez Gene: 13433 Mouse

Entrez Gene: 84350 Rat

Entrez Gene: 30430 Zebrafish

Omim: 126375 Human

SwissProt: Q24K09 Cow

SwissProt: P26358 Human

SwissProt: P13864 Mouse

SwissProt: Q9Z330 Rat

Unigene: 202672 Human

Unigene: 128580 Mouse

Unigene: 6955 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DNA甲基轉(zhuǎn)移酶-1在多種腫瘤細(xì)胞中表達(dá)量相當(dāng)高,而在正常成人細(xì)胞中則低表達(dá),因此dnmt1基因的高表達(dá)與腫瘤的發(fā)生有密切的關(guān)系。 dnmt-1 對細(xì)胞周期、增殖及凋亡有一定的的影響。細(xì)胞核表達(dá)。 (isoform CRA_a)為抑制細(xì)胞增殖、促進(jìn)細(xì)胞凋亡,為腫瘤的基因治療提供依據(jù)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日本55丰满熟妇厨房伦| 高潮影院| 日本免费无码一区二区到五区| 欧美黑人又粗又大的性格特点 | 成人免费毛片AAAAAA片| 精品久久久久久无码人妻热| 亚洲精品无码午夜福利中文字幕| 久久久久亚洲精品中文字幕 | 欧美特黄A级高清免费大片A片 | A片人人澡C片人人人妻| 性欧美大战久久久久久久 | 毛片免费看| 久久久久亚洲AV无码专区首JN| 女人被躁到高潮免费视频| 亚洲AV人人澡人人爽人人夜夜| 中文字幕无码AV波多野吉衣| 无码免费人妻A片AAA毛片一区| 亚洲AV中文无码乱人伦在线视色| 无码熟妇ΑⅤ人妻又粗又大 | 国产传媒果冻天美传媒怎么入职| 无码人妻久久一区二区三区APP| 鸡西市天气预报| 久久久久久久99精品免费观看| 99国产精品无码| АⅤ天堂中文在线网| 农村熟女XXXXHD做受| 国产精品久久久久一区二区三区| 粉嫩XB粉嫩XB粉嫩XB| 朋友销魂的人妻| 一本大道伊人AV久久综合| 青柠在线影院观看日本| 国产精品视频一区| 又白又嫩毛又多15P| 久久久久亚洲AV成人人电影| 成熟人妻换╳╳╳╳| 夜月直播视频直播免费观看| 精品一区二区久久久久久久网站| 天天操,天天干,天天日| 玩弄放荡人妻少妇系列视频| 欧美乱大交XXXXX| 久久精品国产亚洲AV久|