| 產(chǎn)品編號(hào) | bs-0351R-AP |
| 英文名稱1 | Rabbit Anti-GLUT2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的葡萄糖轉(zhuǎn)運(yùn)蛋白2抗體 |
| 別 名 | liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; GLUT-2; GLUT2; GLUT 2; GTR2_HUMAN; SLC2A2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; Solute carrier family 2, facilitated glucose transporter member 2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, Goat, (predicted: Chicken, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLUT2 (465-513aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]. Function: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Liver, insulin-producing beta cell, small intestine and kidney. Post-translational modifications: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. DISEASE: Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. Database links: Entrez Gene: 6514 Human Entrez Gene: 20526 Mouse Omim: 138160 Human SwissProt: P11168 Human SwissProt: P14246 Mouse Unigene: 167584 Human Unigene: 18443 Mouse Unigene: 89295 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 交換和轉(zhuǎn)運(yùn)（Trafficking and Transport） 葡萄糖載運(yùn)蛋白2 GLUT-2是胰島B細(xì)胞膜上的轉(zhuǎn)運(yùn)蛋白，在血糖濃度升高時(shí)，促進(jìn)GLUT2對(duì)葡萄糖的轉(zhuǎn)運(yùn)功能，繼而刺激胰島素釋放。GLUT2分子對(duì)葡萄糖親合力極低，似乎僅在血漿葡萄糖水平相對(duì)較高時(shí)才作為轉(zhuǎn)運(yùn)體發(fā)揮載體功能,GLUT2在胰島B細(xì)胞的葡萄糖轉(zhuǎn)運(yùn)中起著重要作用 GLUT-2和GLUT-4蛋白這兩個(gè)葡萄糖運(yùn)載體的研究對(duì)于糖尿病的胰島素釋放障礙和胰島素抵抗有重要意義 |
