吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
一本一道久久综合狠狠老,国产免费无码一区二区视频
Rabbit Anti-phospho-ITGB3 (Tyr785)/PE-Cy5.5 Conjugated antibody (bs-5452R-PE-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5452R-PE-Cy5.5
英文名稱1 Rabbit Anti-phospho-ITGB3 (Tyr785)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的磷酸化整合素β3抗體
別    名 Integrin beta 3 (phospho Y785); p-Integrin beta 3 (phospho Y785); Integrin beta chain, β3 precursor; Integrin Beta 3; CD 61; CD61; CD61 antigen; GP3A; GPIIIa; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61); Integrin beta chain beta 3; ITG B3; ITGB 3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; platelet glycoprotein IIIa precursor; Platelet membrane glycoprotein IIIa; PTP.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 免疫學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ITGB3 around the phosphorylation site of Tyr785
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The ITGB3 (Integrin beta chain beta 3) protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Function:
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subunit:
Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Post-translational modifications:
Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.

DISEASE:
Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.

Similarity:
Belongs to the integrin beta chain family. Contains 1 VWFA domain.

Database links:

Entrez Gene: 3690 Human

Entrez Gene: 16416 Mouse

Omim: 173470 Human

SwissProt: P05106 Human

SwissProt: O54890 Mouse

Unigene: 218040 Human

Unigene: 87150 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD61抗原又稱為GP III a,是一種表達(dá)于血小板、巨核細(xì)胞、單核細(xì)胞、巨噬細(xì)胞和內(nèi)皮細(xì)胞上的糖蛋白。CD61和CD41構(gòu)成血小板糖蛋白II b/III b。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产成年无码久久久久毛片 | 国产小呦泬泬99精品| 无码人妻一区二区三区在线| 拔萝卜又痛又叫| 一本一道人人妻人人妻ΑV| 久久久久无码精品国产| 欧美色图片区| 校花不着寸缕的跪趴在地下视频 | 欧美成人精品第一区二区三区| 日韩精品一区二区三区色欲AV| 国产精品一亚洲AV日韩AV欧 | 免费av在线| 成人小说亚洲一区二区三区| 亚洲VA欧美VA天堂V国产综合| 亚洲国产精品久久久久久久| 国产精品久久久久一区二区三区| 人妻AV无码一区二区三区| 鸡西市天气预报| 少妇高潮惨叫久久久久电影69| CHINESE老女人老熟妇HD| 国产精品亚洲一区二区三区| 亚洲国产精品久久久久久| 亚洲一区精品无码色成人| 亚洲日韩AV无码中文字幕美国| 欧美人与动性XXXXX杂性| 337P粉嫩大胆色噜噜噜| AV免费网站在线观看| 国产精品人人妻人色五月| 国产成人精品A视频一区| 曰本女人与公拘交酡| 办公室丰满秘书BD正在播放| 国产人妻精品一区二区三区不卡| 日韩AV无码一区二区三区不卡| 精品久久久久久无码中文野结衣| 亚洲精华国产精华精华液网站| 在线永久免费观看黄网站| 性一交一乱一乱一视频| 亚洲精品无码成人片久久不卡| 岳把我用嘴含进满足我视频| 在线观看免费人成视频| 无码熟熟妇丰满人妻啪啪|