吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲欧美日韩久久精品第一区,亚洲AV无码乱码国产精品,日韩AV高清在线观看
Rabbit Anti-phospho-MEK1 (Thr386)/PE-Cy5.5 Conjugated antibody (bs-5413R-PE-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5413R-PE-Cy5.5
英文名稱1 Rabbit Anti-phospho-MEK1 (Thr386)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的磷酸化絲裂原活化蛋白激酶1抗體
別    名 MEK1 (phospho Thr386); MEK1 (phospho T386); p-MEK1 (Thr386); p-MEK1 (T386); Dual specificity mitogen activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAP/Erk kinase 1; Map2K1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEKK1; Mitogen activated protein kinase kinase 1; MKK 1; MKK1; PRKMK 1; PRKMK1;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1); Protein kinase mitogen activated kinase 1; Protein kinase mitogen activated, kinase 1; MP2K1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Pig, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEK1 around the phosphorylation site of Thr386
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Subunit:
Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms an heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2. Interacts with Yersinia yopJ. Interacts with SGK1. Interacts with BIRC6/bruce.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis.

Tissue Specificity:
Widely expressed, with extremely low levels in brain.

Post-translational modifications:
Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5604 Human

Entrez Gene: 26395 Mouse

Entrez Gene: 170851 Rat

Omim: 176872 Human

SwissProt: Q02750 Human

SwissProt: P31938 Mouse

SwissProt: Q01986 Rat

Unigene: 145442 Human

Unigene: 248907 Mouse

Unigene: 5850 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

絲裂原活化蛋白激酶是一組可以被多種細(xì)胞外信號(hào)即獲得蛋白絲/蘇氨酸激酶,處于胞漿信號(hào)傳導(dǎo)通路的終末位置,活化后轉(zhuǎn)位到核內(nèi),作用于核內(nèi)轉(zhuǎn)錄因子,調(diào)節(jié)基因表達(dá)。它主要參與生長(zhǎng)因子、激素、細(xì)胞因子、應(yīng)激等各種刺激下細(xì)胞的反應(yīng)、細(xì)胞的生長(zhǎng)、分化過(guò)程。經(jīng)研究證實(shí),MAPK信號(hào)轉(zhuǎn)導(dǎo)通路存在于大多數(shù)細(xì)胞內(nèi),在將細(xì)胞外刺激信號(hào)轉(zhuǎn)導(dǎo)至細(xì)胞及其核內(nèi),并引起細(xì)胞生物學(xué)反應(yīng)(如細(xì)胞增殖、分化、轉(zhuǎn)化及凋亡等)的過(guò)程中具有至關(guān)重要的作用。研究表明,MAPK信號(hào)轉(zhuǎn)導(dǎo)通路在細(xì)胞內(nèi)具有生物進(jìn)化的高度保守性,在低等原核細(xì)胞和高等哺乳類細(xì)胞內(nèi),目前均已發(fā)現(xiàn)存在著多條并行的MAPK信號(hào)通路,不同的細(xì)胞外刺激可使用不同的MAPK信號(hào)通路,通過(guò)其相互調(diào)控而介導(dǎo)不同的細(xì)胞生物學(xué)反應(yīng)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
美女露出奶头扒开尿口| 少妇人妻丰满做爰XXX| 色综合久久久久综合99| 日本乱妇乱熟乱妇乱色A片| 少妇被粗大的猛烈进出A片久久久 极品少妇被猛得白浆直流草莓视频 | 国产一区二区在线视频| 中文字幕丰满伦子无码| NBA直播在线观看免费| 国产乱码一区二区三区| 狠狠色综合7777久夜色撩人,| 天天躁日日躁狠狠躁| 久久精品女人天堂AV免费观看| 麻豆亚洲AV熟女国产一区二| 精品久久香蕉国产线看观看亚洲| XXXX18一20岁HD第一次| 久久精品人妻一区二区三区| 国产成人精品一区二区三区免费| 国内精品视频一区二区三区八戒| 人物动物交互狗AA| 亚洲中文字幕无码AV永久 | 欧美JIZZ18性欧美| 免费三级网站| 国产成人午夜精品久久久久久| 久久高清内射无套| 国产精品自产拍高潮在线观看| 久久久久久久精品无码AV少妇| 国产AV人人夜夜澡人人爽麻豆 | 三个男人躁我一个阿啊阿广告| 羞羞漫画官网| 人妻少妇一区二区三区| 国偷自产AV一区二区三区123| 色婷婷av一区二区三区| 妻子4免费完整版中文版| 亚洲精品久久久久69影院| 久久久久黑人强伦姧人妻| 办公室撕开奶罩揉吮奶漫画 | 国产AV亚洲精品久久久久 | 欧美精品视频| 6080YYY午夜理论片中无码| 最新69成人国产精品视频免费| 人妻精油按摩BD高清中文字幕|