| 產(chǎn)品編號 | bs-4121R-BF488 |
| 英文名稱1 | Rabbit Anti-Exendin 4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的GLP1類似蛋白Exendin4抗體 |
| 別 名 | Exendin 4; Exendin4; Exendin-4; EXE4_HELSU . |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4.3kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. Function: Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. Subcellular Location: Secreted. Tissue Specificity: Expressed by the venom gland. Similarity: Belongs to the glucagon family. Database links: UniProtKB/Swiss-Prot: P26349.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Exendin-4是從希拉毒蜥唾液中分離的一種多肽激素,由39個氨基酸殘基組成,與胰高血糖素樣肽1(GLP-1)有53%的同源性。Exendin-4具有高度的組織特異性,僅在希拉毒蜥的唾液腺中表達(dá), 具有促進(jìn)葡萄糖依賴性的胰島素分泌、促進(jìn)β細(xì)胞增殖、減慢胃排空、抑制食物攝取和減輕體重等作用。 腸促胰島素類似物（exendin-4，Ex-4）是從美洲一種毒蜥的唾液中分泌的胰升糖素樣肽-1（glucagon-like peptide-1，GLP-1）類似物，它具有促進(jìn)胰腺胰島素的分泌、增加胰島素敏感性及改善胰島細(xì)胞功能的作用，且不被二肽基肽酶Ⅳ（DPP-Ⅳ）分解，血漿半衰期較長，因而在人類，對糖尿病治療應(yīng)用來說是穩(wěn)定、長效的有治療前景的藥物。 鈍尾毒蜥 (Gila monster) |
