吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
97视频在线观看,老妇性hqmaturetube,成人午夜亚洲精品无码网站
Rabbit Anti-phospho-MEF2C(Ser396)/PE Conjugated antibody (bs-5480R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5480R-PE
英文名稱1 Rabbit Anti-phospho-MEF2C(Ser396)/PE Conjugated antibody
中文名稱 PE標(biāo)記的磷酸化肌細(xì)胞增強(qiáng)因子2C抗體
別    名 MEF2C (phospho S396); p-MEF2C (phospho S396); MEF2C(phospho S396); MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C); Myocyte enhancer factor 2C; Myocyte specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C; MEF2C_HUMAN.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Pig, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEF2C around the phosphorylation site of Ser396
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.

Function:
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. Interacts with MYOCD (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain and skeletal muscle.

Post-translational modifications:
Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.
Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.
Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.
Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

DISEASE:
Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

Database links:

Entrez Gene: 512254 Cow

Entrez Gene: 4208 Human

Entrez Gene: 17260 Mouse

Entrez Gene: 733590 Pig

Entrez Gene: 499497 Rat

Omim: 600662 Human

SwissProt: Q2KIA0 Cow

SwissProt: Q06413 Human

SwissProt: Q8CFN5 Mouse

SwissProt: A4UTP7 Pig

Unigene: 649965 Human

Unigene: 24001 Mouse

Unigene: 451574 Mouse

Unigene: 484098 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
999久久久国产精品| 国产成人精品无码一区二区| 重囗味SM在线观看无码| 国精产品一品二品国精破解| 无码精品人妻一区二区三区AV | 国产精品一区二区在线观看| 99精品国产一区二区| 欧美裸体XXXX极品少妇| 奇米影视777| 久久久久亚洲AV片无码| 成人动漫在线观看| 日韩视频在线观看| 亚洲欧美日韩久久精品| 亚洲AV无码乱码国产麻豆| 免费A级毛片在线播放不收费| 宝贝在街上把奶露出来H| 又湿又紧又大又爽A视频| 欧美乱妇狂野欧美在线视频| 亚洲欧美日韩在线不卡| 女人高潮真实叫床声MP3| 中国老熟女重囗味HDXX| 精品欧美А∨无码黑人| 18禁男女爽爽爽午夜网站免费| 国产免费一区二区三区在线观看| 国产一区二区三区成人欧美日韩在线观看| 亚洲综合AV一区二区三区| 亚洲人成人无码网WWW国产| 天美传媒免费观看一二三在线| 无码少妇一区二区| 久久亚洲AV午夜福利精品一区| 99久久国产热无码精品免费| 在办公室伦流澡到高潮H| 国产第一页屁屁影院| 免费人妻精品一区二区三区| 国产精品无码专区AV在线播放| 年轻漂亮的女教师| 国产午夜精品一区二区| 女人被强╳到高潮喷水在线观看 | 日本亲近相奷中文字幕| 久久久久成人精品无码| 6080YYY午夜理论片中无码|